Distribution of CC-chemokine Receptor-5-∆32 Allele Among the Tribal and Caste Population of Vidarbha Region of Maharashtra State

Overview

Journal Indian J Hum Genet

Specialty Genetics

Date 2013 Aug 1

PMID 23901195

Citations 1

Authors

Arvind B Chavhan

Santosh S Pawar

Rajusing G Jadhao

Kishor G Patil

Affiliations

Soon will be listed here.

Abstract

Background: Genetic relationships among the ethnic groups are not uniform across the geographical region. Considering this assumption, we analyzed the frequency of the CC-chemokine receptor-5 (CCR5)-∆32 allele of the CCR5 chemokine receptor, which is considered a Caucasian marker, in Bhil tribal and Brahmin caste sample sets from the population.

Materials And Methods: 108 blood samples were collected from 6 tribe's populations and a caste population from the district of Vidarbha region.

Results And Discussion: The presence of low frequencies of CCR5-Δ32 in an individual of Bhil tribe (0.034, χ(2) value 0.017) in the present study implies that these communities may have a better resistance toward human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) than the other studied tribe sample, as non-show such mutation.

Conclusion: The marginal presence of the allele seen in the studied tribal population could be due to gene flow from the people of European descent. However, lack of the homozygous CCR5-Δ32 mutation and the low prevalence of heterozygous CCR5-Δ32 mutations suggest that the Indians are highly susceptible to HIV/AIDS, and this correlates with the highest number of HIV/AIDS infected individuals in India.

Citing Articles

Association analysis and allelic distribution of deletion in CC chemokine receptor 5 gene (CCR5Δ32) among breast cancer patients of Pakistan.

Fatima F, Saleem S, Hameed A, Haider G, Zaidi S, Kanwal M Mol Biol Rep. 2019; 46(2):2387-2394.

PMID: 30848448 DOI: 10.1007/s11033-019-04699-6.

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