Phyto-SERM Constitutes from Flemingia Macrophylla

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2013 Jul 31

PMID 23896592

Citations 4

Authors

Wan-Chun Lai

Ya-Ting Tsui

Abdel Nasser B Singab

Mohamed El-Shazly

Ying-Chi Du

Tsong-Long Hwang

Chin-Chung Wu

Ming-Hong Yen

Ching-Kuo Lee

Ming-Feng Hou

Yang-Chang Wu

Fang-Rong Chang

Affiliations

Soon will be listed here.

Abstract

The methanolic extract of Flemingia macrophylla roots exhibited significant estrogenic activity in the transgenic plant assay system which was comparable to the activity of soybean extract. Utilizing estrogenic activity-guided fractionation, one new compound, fleminigin, together with 23 known compounds were isolated from F. macrophylla roots' methanolic extract. The structure of the new compound was identified based on intensive spectroscopic analysis and the full spectral data for one of the isolated compounds, flemichin E, was introduced for the first time in the current investigation. The estrogenic and anti-estrogenic activities of the isolated compounds were evaluated revealing that the isolated isoflavonoids may act as partial estrogen agonists, as well as antagonists. Additionally, the anti-inflammatory and the cytotoxic activities of the isolated compounds were studied. These results suggested the potential applications of F. macrophylla extract and its isolated compounds as selective estrogen receptor modulators (SERMs).

Citing Articles

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