A Higher Risk of Acute Rejection of Human Kidney Allografts Can Be Predicted from the Level of CD45RC Expressed by the Recipients' CD8 T Cells

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Jul 30

PMID 23894540

Citations 12

Authors

Laurence Ordonez

Isabelle Bernard

Marianne Chabod

Jean-Francois Augusto

Valerie Lauwers-Cances

Christelle Cristini

Maria-Cristina Cuturi

Jean-Francois Subra

Abdelhadi Saoudi

Affiliations

Soon will be listed here.

Abstract

Although transplantation is the common treatment for end-stage renal failure, allograft rejection and marked morbidity from the use of immunosuppressive drugs remain important limitations. A major challenge in the field is to identify easy, reliable and noninvasive biomarkers allowing the prediction of deleterious alloreactive immune responses and the tailoring of immunosuppressive therapy in individuals according to the rejection risk. In this study, we first established that the expression of the RC isoform of the CD45 molecule (CD45RC) on CD4 and CD8 T cells from healthy individuals identifies functionally distinct alloreactive T cell subsets that behave differently in terms of proliferation and cytokine secretion. We then investigated whether the frequency of the recipients CD45RC T cell subsets before transplantation would predict acute graft rejection in a cohort of 89 patients who had undergone their first kidney transplantation. We showed that patients exhibiting more than 54.7% of CD8 CD45RC(high) T cells before transplantation had a 6 fold increased risk of acute kidney graft rejection. In contrast, the proportions of CD4 CD45RC T cells were not predictive. Thus, a higher risk of acute rejection of human kidney allografts can be predicted from the level of CD45RC expressed by the recipients' CD8 T cells.

Citing Articles

Renal graft function in transplanted patients correlates with CD45RC T cell phenotypic signature.

Bezie S, Serazin C, Autrusseau E, Vimond N, Giral M, Anegon I PLoS One. 2024; 19(3):e0300032.

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Kidney double positive T cells have distinct characteristics in normal and diseased kidneys.

Noel S, Newman-Rivera A, Lee K, Gharaie S, Patel S, Singla N Sci Rep. 2024; 14(1):4469.

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An Immune Atlas of T Cells in Transplant Rejection: Pathways and Therapeutic Opportunities.

Short S, Lewik G, Issa F Transplantation. 2023; 107(11):2341-2352.

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Cytotoxic T Lymphocytes (CTLs) and Kidney Transplantation: An Overview.

Rascio F, Pontrelli P, Grandaliano G Methods Mol Biol. 2021; 2325:203-213.

PMID: 34053060 DOI: 10.1007/978-1-0716-1507-2_14.

CD45RC Expression of Circulating CD8 T Cells Predicts Acute Allograft Rejection: A Cohort Study of 128 Kidney Transplant Patients.

Lemerle M, Garnier A, Planchais M, Brilland B, Subra J, Blanchet O J Clin Med. 2019; 8(8).

PMID: 31374966 PMC: 6723395. DOI: 10.3390/jcm8081147.

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