Association of Myeloperoxidase with Ovarian Cancer

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2013 Jul 30

PMID 23893381

Citations 18

Authors

Dan Cacsire Castillo-Tong

Dietmar Pils

Georg Heinze

Ioana Braicu

Jalid Sehouli

Alexander Reinthaller

Eva Schuster

Andrea Wolf

Rafal Watrowski

Richard A Maki

Robert Zeillinger

Wanda F Reynolds

Affiliations

Soon will be listed here.

Abstract

Myeloperoxidase (MPO) is an oxidant generating enzyme normally restricted to myeloid cells, however aberrant MPO expression has been found to occur in non-myeloid cells in some disease states. The functional -463GA promoter polymorphism alters MPO expression levels. The -463G is within an SP1 binding site and is associated with higher gene expression. The G allele is most frequent with ~62% of European populations being GG homozygotes. The GA polymorphism has been associated with risk or survival in a variety of cancers including lung and breast cancer. In this study we determined the frequency of the -463G/A polymorphism in 230 ovarian cancer patients, 75 patients with borderline ovarian tumors, and 299 healthy controls. The GG genotype was found to be overrepresented in patients with early stage ovarian cancer (83.3% GG, p = 0.008) as compared to healthy controls (62% GG), suggesting that MPO oxidants may increase risk. Immunohistochemical analysis revealed MPO expression in a subset of columnar ovarian epithelial carcinoma cells in early stage carcinomas.

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