Effect of Eurycomanone on Cytochrome P450 Isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 in Vitro

Overview

Journal J Nat Med

Publisher Springer

Date 2013 Jul 25

PMID 23881640

Citations 8

Authors

Yan Pan

Kai Hung Tiong

Badrul Amini Abd-Rashid

Zakiah Ismail

Rusli Ismail

Joon Wah Mak

Chin Eng Ong

Affiliations

Soon will be listed here.

Abstract

Eurycomanone, an active constituent isolated from Eurycoma longifolia Jack, was examined for modulatory effects on cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 using in vitro assays. The IC50 value was determined to assess the potencies of modulation for each CYP isoform. Our results indicated that eurycomanone did not potently inhibit any of the CYP isoforms investigated, with IC50 values greater than 250 μg/ml. Hence there appears to be little likelihood of drug-herb interaction between eurycomanone or herbal products with high content of this compound and CYP drug substrates via CYP inhibition.

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