Use of Quantitative Diffusion-weighted Magnetic Resonance Imaging to Predict Human Papilloma Virus Status in Patients with Oropharyngeal Squamous Cell Carcinoma

Overview

Journal Eur Arch Otorhinolaryngol

Specialty Otorhinolaryngology

Date 2013 Jul 25

PMID 23880924

Citations 27

Authors

Mitsuhiko Nakahira

Naoko Saito

Hiroshi Yamaguchi

Kiyomi Kuba

Masashi Sugasawa

Affiliations

Soon will be listed here.

Abstract

Although identification of human papilloma virus (HPV) status in oropharyngeal squamous cell carcinoma (OPSCC) is essential in predicting treatment response, no imaging modality can currently determine whether a tumor is HPV-related. In this retrospective study, 26 patients with OPSCC confined to the lateral wall or the base of tongue underwent neck magnetic resonance imaging, using T1-, T2- and diffusion-weighted imaging (DWI). Apparent diffusion coefficients (ADCs) in a region of interest covering the largest available primary tumor area of OPSCC on a single slice of the ADC map were calculated using two b values (0 and 1,000 s/mm(2)). Mean and minimum ADCs were compared with HPV status, using p16 immunohistochemistry as a surrogate marker for HPV infection. Mean and minimum ADCs for HPV(+) OPSCC were significantly lower than those for HPV(-) OPSCC. A cut-off value of mean ADC for HPV(+) OPSCC of 1.027 × 10(-3) mm(2)/s yielded sensitivity and specificity of 83.33 and 78.57%, respectively. In conclusion, the present study indicates that ADC could be used to predict HPV status in patients with OPSCC.

Citing Articles

Diffusion-Weighted MRI and Human Papillomavirus (HPV) Status in Oropharyngeal Cancer.

Bollen H, Dok R, De Keyzer F, Deschuymer S, Laenen A, Devos J Cancers (Basel). 2025; 16(24.

PMID: 39766182 PMC: 11674353. DOI: 10.3390/cancers16244284.

MRI for Differentiation between HPV-Positive and HPV-Negative Oropharyngeal Squamous Cell Carcinoma: A Systematic Review.

Chen L, Lauwers I, Verduijn G, Philippens M, Gahrmann R, Capala M Cancers (Basel). 2024; 16(11).

PMID: 38893224 PMC: 11171338. DOI: 10.3390/cancers16112105.

Relating pre-treatment non-Gaussian intravoxel incoherent motion diffusion-weighted imaging to human papillomavirus status and response in oropharyngeal carcinoma.

Sijtsema N, Lauwers I, Verduijn G, Hoogeman M, Poot D, Hernandez-Tamames J Phys Imaging Radiat Oncol. 2024; 30:100574.

PMID: 38633282 PMC: 11021835. DOI: 10.1016/j.phro.2024.100574.

The Prediction of Biological Features Using Magnetic Resonance Imaging in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

van der Hulst H, Jansen R, Vens C, Bos P, Schats W, de Jong M Cancers (Basel). 2023; 15(20).

PMID: 37894447 PMC: 10605807. DOI: 10.3390/cancers15205077.

Multiparametric MRI-based radiomics model for predicting human papillomavirus status in oropharyngeal squamous cell carcinoma: optimization using oversampling and machine learning techniques.

Sim Y, Kim M, Kim J, Lee S, Han K, Sohn B Eur Radiol. 2023; 34(5):3102-3112.

PMID: 37848774 DOI: 10.1007/s00330-023-10338-3.

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