The Role of Apelin in the Retina of Diabetic Rats

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Jul 23

PMID 23874984

Citations 7

Authors

Qiang Lu

Jing Feng

Yan-Rong Jiang

Affiliations

Soon will be listed here.

Abstract

Purpose: Apelin is a novel adipocytokine participating in diabetes, but its role in diabetic retinopathy (DR) is unknown. Our study aimed to investigate the effect of apelin on the proliferative potential in DR along with its antagonist inhibitory effects.

Principal Findings: Strong staining of apelin, co-localized with glial fibrillary acidic protein (GFAP) and vascular endothelial growth factor (VEGF) was observed in the retina of diabetic rats. Apelin, GFAP, and VEGF mRNA and protein levels were significantly increased in the sample's retinas. Moreover, exogenous apelin promoted retinal Müller cell proliferation in vivo. Simultaneously, apelin induced GFAP and VEGF expression. F13A markedly reduced retinal gliosis caused by diabetes. Furthermore, F13A suppressed both GFAP and VEGF expression in vivo.

Significance: Our results strongly suggest that apelin is associated with the development of DR and contributes to changes in the retinas of diabetic rats. Apelin induced promotion of cell proliferation lends support to the possibility that apelin may play a role in the progression of DR to a proliferative phase. This possible role deserves further investigation, which may offer new perspectives in the early prevention and treatment of DR.

Citing Articles

The Yin and Yang Effect of the Apelinergic System in Oxidative Stress.

Fibbi B, Marroncini G, Naldi L, Peri A Int J Mol Sci. 2023; 24(5).

PMID: 36902176 PMC: 10003082. DOI: 10.3390/ijms24054745.

Correlation between apelin and VEGF levels in retinopathy of prematurity: a matched case-control study.

Zhang Y, Feng J, Shao S, Mu Q, Liu J, Zeng C BMC Ophthalmol. 2022; 22(1):342.

PMID: 35953806 PMC: 9373384. DOI: 10.1186/s12886-022-02565-x.

The therapeutic potential of apelin in kidney disease.

Chapman F, Nyimanu D, Maguire J, Davenport A, Newby D, Dhaun N Nat Rev Nephrol. 2021; 17(12):840-853.

PMID: 34389827 PMC: 8361827. DOI: 10.1038/s41581-021-00461-z.

Apelin-13 Is an Early Promoter of Cytoskeleton and Tight Junction in Diabetic Macular Edema via PI-3K/Akt and MAPK/Erk Signaling Pathways.

Li Y, Bai Y, Jiang Y, Yu W, Shi X, Chen L Biomed Res Int. 2018; 2018:3242574.

PMID: 29850504 PMC: 5904819. DOI: 10.1155/2018/3242574.

Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.

Le Gonidec S, Chaves-Almagro C, Bai Y, Kang H, Smith A, Wanecq E FASEB J. 2017; 31(6):2507-2519.

PMID: 28242772 PMC: 6191096. DOI: 10.1096/fj.201601074R.

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