Pheochromocytoma in an 8-year-old Patient with Multiple Endocrine Neoplasia Type 2A: Implications for Screening

Overview

Journal J Surg Oncol

Specialties General Surgery
Oncology

Date 2013 Jul 23

PMID 23868299

Citations 8

Authors

Kathryn J Rowland

Rebecca D Chernock

Jeffrey F Moley

Affiliations

Soon will be listed here.

Abstract

Childhood pheochromocytoma in the setting of multiple endocrine neoplasia type 2 (MEN2) remains rare and has not been reported under the age of 12. We present an 8-year-old female with known MEN 2A, C634Y RET mutation, diagnosed with a 6 cm pheochromocytoma requiring laparoscopic adrenalectomy. Given this patient's age at diagnosis, screening guidelines should recommend annual screening beginning at age 8 for patients with MEN 2B or MEN 2A codons 630 or 634 RET mutations.

Citing Articles

Childhood Multiple Endocrine Neoplasia (MEN) Syndromes: Genetics, Clinical Heterogeneity and Modifying Genes.

Lanzaro F, De Biasio D, Cesaro F, Stampone E, Tartaglione I, Casale M J Clin Med. 2024; 13(18).

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Amodru V, Taieb D, Guerin C, Romanet P, Paladino N, Brue T Endocrine. 2020; 69(3):496-503.

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Pheochromocytoma in Children and Adolescents With Multiple Endocrine Neoplasia Type 2B.

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A Clinical Roadmap to Investigate the Genetic Basis of Pediatric Pheochromocytoma: Which Genes Should Physicians Think About?.

Pereira B, Nunes da Silva T, Bernardo A, Cesar R, Luiz H, Pacak K Int J Endocrinol. 2018; 2018:8470642.

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Minimally Invasive Surgery (MIS) in Children and Adolescents with Pheochromocytomas and Retroperitoneal Paragangliomas: Experiences in 42 Patients.

Walz M, Iova L, Deimel J, Neumann H, Bausch B, Zschiedrich S World J Surg. 2018; 42(4):1024-1030.

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