Quantification of Magnetic Nanoparticles with Low Frequency Magnetic Fields: Compensating for Relaxation Effects

Overview

Journal Nanotechnology

Specialty Biotechnology

Date 2013 Jul 23

PMID 23867287

Citations 11

Authors

John B Weaver

Xiaojuan Zhang

Esra Kuehlert

Seiko Toraya-Brown

Daniel B Reeves

Irina M Perreard

Steven Fiering

Affiliations

Soon will be listed here.

Abstract

Quantifying the number of nanoparticles present in tissue is central to many in vivo and in vitro applications. Magnetic nanoparticles can be detected with high sensitivity both in vivo and in vitro using the harmonics of their magnetization produced in a sinusoidal magnetic field. However, relaxation effects damp the magnetic harmonics rendering them of limited use in quantification. We show that an accurate measure of the number of nanoparticles can be made by correcting for relaxation effects. Correction for relaxation reduced errors of 50% for larger nanoparticles in high relaxation environments to 2%. The result is a method of nanoparticle quantification suitable for in vivo and in vitro applications including histopathology assays, quantitative imaging, drug delivery and thermal therapy preparation.

Citing Articles

Magnetic Particle Spectroscopy for Point-of-Care: A Review on Recent Advances.

Yari P, Rezaei B, Dey C, Chugh V, Veerla N, Wang J Sensors (Basel). 2023; 23(9).

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Novel Benchtop Magnetic Particle Spectrometer for Process Monitoring of Magnetic Nanoparticle Synthesis.

Lowa N, Gutkelch D, Welge E, Welz R, Meier F, Baki A Nanomaterials (Basel). 2020; 10(11).

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Identifying in vivo inflammation using magnetic nanoparticle spectra.

Weaver J, Ness D, Fields J, Jyoti D, Gordon-Wylie S, Berwin B Phys Med Biol. 2020; 65(12):125003.

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Heating Efficiency of Triple Vortex State Cylindrical Magnetic Nanoparticles.

Wong D, Gan W, Teo Y, Lew W Nanoscale Res Lett. 2019; 14(1):376.

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Quantification of magnetic nanoparticles by compensating for multiple environment changes simultaneously.

Shi Y, Jyoti D, Gordon-Wylie S, Weaver J Nanoscale. 2019; 12(1):195-200.

PMID: 31807744 PMC: 6936736. DOI: 10.1039/c9nr08258a.

References

Peiris P, Bauer L, Toy R, Tran E, Pansky J, Doolittle E . Enhanced delivery of chemotherapy to tumors using a multicomponent nanochain with radio-frequency-tunable drug release. ACS Nano. 2012; 6(5):4157-68. PMC: 3358486. DOI: 10.1021/nn300652p. View

Ferguson R, Minard K, Krishnan K . Optimization of nanoparticle core size for magnetic particle imaging. J Magn Magn Mater. 2009; 321(10):1548-1551. PMC: 2709850. DOI: 10.1016/j.jmmm.2009.02.083. View

Reeves D, Weaver J . Simulations of magnetic nanoparticle Brownian motion. J Appl Phys. 2013; 112(12):124311. PMC: 3537703. DOI: 10.1063/1.4770322. View

Jun Y, Seo J, Cheon J . Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences. Acc Chem Res. 2008; 41(2):179-89. DOI: 10.1021/ar700121f. View

Lopez A, Gutierrez L, Lazaro F . The role of dipolar interaction in the quantitative determination of particulate magnetic carriers in biological tissues. Phys Med Biol. 2007; 52(16):5043-56. DOI: 10.1088/0031-9155/52/16/022. View

Dennis C, Jackson A, Borchers J, Hoopes P, Strawbridge R, Foreman A . Nearly complete regression of tumors via collective behavior of magnetic nanoparticles in hyperthermia. Nanotechnology. 2009; 20(39):395103. PMC: 4086622. DOI: 10.1088/0957-4484/20/39/395103. View

Weaver J, Rauwerdink A, Hansen E . Magnetic nanoparticle temperature estimation. Med Phys. 2009; 36(5):1822-9. PMC: 4109636. DOI: 10.1118/1.3106342. View

Gleich B, Weizenecker J . Tomographic imaging using the nonlinear response of magnetic particles. Nature. 2005; 435(7046):1214-7. DOI: 10.1038/nature03808. View

Rauwerdink A, Weaver J . Concurrent quantification of multiple nanoparticle bound states. Med Phys. 2011; 38(3):1136-40. PMC: 3055696. DOI: 10.1118/1.3549762. View

10.

Goodwill P, Scott G, Stang P, Conolly S . Narrowband magnetic particle imaging. IEEE Trans Med Imaging. 2009; 28(8):1231-7. DOI: 10.1109/TMI.2009.2013849. View

11.

Weaver J, Rauwerdink A, Sullivan C, Baker I . Frequency distribution of the nanoparticle magnetization in the presence of a static as well as a harmonic magnetic field. Med Phys. 2008; 35(5):1988-94. PMC: 4108637. DOI: 10.1118/1.2903449. View

12.

Giustini A, Ivkov R, Hoopes P . Magnetic nanoparticle biodistribution following intratumoral administration. Nanotechnology. 2011; 22(34):345101. PMC: 3158492. DOI: 10.1088/0957-4484/22/34/345101. View

13.

Rauwerdink A, Weaver J . Harmonic phase angle as a concentration-independent measure of nanoparticle dynamics. Med Phys. 2010; 37(6):2587-92. PMC: 3138797. DOI: 10.1118/1.3426294. View

14.

Brigger I, Dubernet C, Couvreur P . Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev. 2002; 54(5):631-51. DOI: 10.1016/s0169-409x(02)00044-3. View

15.

Knopp T, Biederer S, Sattel T, Weizenecker J, Gleich B, Borgert J . Trajectory analysis for magnetic particle imaging. Phys Med Biol. 2008; 54(2):385-97. DOI: 10.1088/0031-9155/54/2/014. View

16.

Rauwerdink A, Hansen E, Weaver J . Nanoparticle temperature estimation in combined ac and dc magnetic fields. Phys Med Biol. 2009; 54(19):L51-5. PMC: 3757125. DOI: 10.1088/0031-9155/54/19/L01. View

17.

Weaver J, Kuehlert E . Measurement of magnetic nanoparticle relaxation time. Med Phys. 2012; 39(5):2765-70. PMC: 3350541. DOI: 10.1118/1.3701775. View

18.

Weizenecker J, Gleich B, Rahmer J, Dahnke H, Borgert J . Three-dimensional real-time in vivo magnetic particle imaging. Phys Med Biol. 2009; 54(5):L1-L10. DOI: 10.1088/0031-9155/54/5/L01. View