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» Articles » PMID: 23866846

Viral Load Dynamics in Adult Patients with A(H1N1)pdm09 Influenza

Overview
Journal Epidemiol Infect
Publisher Cambridge University Press
Specialties Infectious Diseases
Public Health
Date 2013 Jul 23
PMID 23866846
Citations 8
Authors
J Y Noh
J Y Song
S Y Hwang
W S Choi
J Y Heo
H J Cheong
W J Kim
Affiliations
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Abstract

SUMMARY The dynamics of influenza A viral load in respiratory samples collected from adult A(H1N1)pdm09 influenza patients were investigated. Three respiratory specimens were obtained every 2-4 days and clinical findings were recorded at the time each specimen was collected. A total of 105 serial specimens were collected from 35 patients. Viral clearance was more rapid in patients aged 15-29 years than patients aged 30-49 years (P < 0.01) or ≥ 50 years (P < 0.01). Hospitalized patients showed slow viral clearance compared to outpatients (P < 0.01). Resolution of cough and headache was correlated with viral load reduction in respiratory specimens. Viral shedding was found in 17 patients (48.6%) 5 days after symptom onset. Time to hospital visit after symptom onset was significantly correlated with prolonged viral shedding (odds ratio 9.0, 95% confidence interval 1.56-51.87, P = 0.01). These findings will contribute to infection control aspects with respect to managing patients with influenza virus infections.

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