Secondary Neutron Dose Measurement for Proton Eye Treatment Using an Eye Snout with a Borated Neutron Absorber

Overview

Journal Radiat Oncol

Publisher Biomed Central

Specialties Oncology
Radiology

Date 2013 Jul 20

PMID 23866307

Authors

Dong Wook Kim

Weon Kuu Chung

Jungwook Shin

Young Kyung Lim

Dongho Shin

Se Byeong Lee

Myongguen Yoon

Sung-Yong Park

Dong Oh Shin

Jung Keun Cho

Affiliations

Soon will be listed here.

Abstract

Background: We measured and assessed ways to reduce the secondary neutron dose from a system for proton eye treatment.

Methods: Proton beams of 60.30 MeV were delivered through an eye-treatment snout in passive scattering mode. Allyl diglycol carbonate (CR-39) etch detectors were used to measure the neutron dose in the external field at 0.00, 1.64, and 6.00 cm depths in a water phantom. Secondary neutron doses were measured and compared between those with and without a high-hydrogen-boron-containing block. In addition, the neutron energy and vertices distribution were obtained by using a Geant4 Monte Carlo simulation.

Results: The ratio of the maximum neutron dose equivalent to the proton absorbed dose (H(10)/D) at 2.00 cm from the beam field edge was 8.79 ± 1.28 mSv/Gy. The ratio of the neutron dose equivalent to the proton absorbed dose with and without a high hydrogen-boron containing block was 0.63 ± 0.06 to 1.15 ± 0.13 mSv/Gy at 2.00 cm from the edge of the field at depths of 0.00, 1.64, and 6.00 cm.

Conclusions: We found that the out-of-field secondary neutron dose in proton eye treatment with an eye snout is relatively small, and it can be further reduced by installing a borated neutron absorbing material.

References

Bonnett D, Kacperek A, Sheen M, Goodall R, Saxton T . The 62 MeV proton beam for the treatment of ocular melanoma at Clatterbridge. Br J Radiol. 1993; 66(790):907-14. DOI: 10.1259/0007-1285-66-790-907. View

Jarlskog C, Paganetti H . Sensitivity of different dose scoring methods on organ-specific neutron dose calculations in proton therapy. Phys Med Biol. 2008; 53(17):4523-32. DOI: 10.1088/0031-9155/53/17/004. View

Goitein M, Miller T . Planning proton therapy of the eye. Med Phys. 1983; 10(3):275-83. DOI: 10.1118/1.595258. View

Moyers M, Benton E, Ghebremedhin A, Coutrakon G . Leakage and scatter radiation from a double scattering based proton beamline. Med Phys. 2008; 35(1):128-44. DOI: 10.1118/1.2805086. View

Perez-Andujar A, Newhauser W, Deluca P . Neutron production from beam-modifying devices in a modern double scattering proton therapy beam delivery system. Phys Med Biol. 2009; 54(4):993-1008. PMC: 4136452. DOI: 10.1088/0031-9155/54/4/012. View

Olsher R, Hsu H, Beverding A, Kleck J, Casson W, Vasilik D . WENDI: an improved neutron rem meter. Health Phys. 2000; 79(2):170-81. DOI: 10.1097/00004032-200008000-00010. View

Fontenot J, Taddei P, Zheng Y, Mirkovic D, Jordan T, Newhauser W . Equivalent dose and effective dose from stray radiation during passively scattered proton radiotherapy for prostate cancer. Phys Med Biol. 2008; 53(6):1677-88. DOI: 10.1088/0031-9155/53/6/012. View

Wroe A, Clasie B, Kooy H, Flanz J, Schulte R, Rosenfeld A . Out-of-field dose equivalents delivered by passively scattered therapeutic proton beams for clinically relevant field configurations. Int J Radiat Oncol Biol Phys. 2008; 73(1):306-13. DOI: 10.1016/j.ijrobp.2008.09.030. View

Paganetti H, Bortfeld T, DeLaney T . Neutron dose in proton radiation therapy: in regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1-7). Int J Radiat Oncol Biol Phys. 2006; 66(5):1594-5. DOI: 10.1016/j.ijrobp.2006.08.005. View

10.

Jiang H, Wang B, Xu X, Suit H, Paganetti H . Simulation of organ-specific patient effective dose due to secondary neutrons in proton radiation treatment. Phys Med Biol. 2005; 50(18):4337-53. DOI: 10.1088/0031-9155/50/18/007. View

11.

Polf J, Newhauser W, Titt U . Patient neutron dose equivalent exposures outside of the proton therapy treatment field. Radiat Prot Dosimetry. 2005; 115(1-4):154-8. DOI: 10.1093/rpd/nci264. View

12.

Brenner D, Elliston C, Hall E, Paganetti H . Reduction of the secondary neutron dose in passively scattered proton radiotherapy, using an optimized pre-collimator/collimator. Phys Med Biol. 2009; 54(20):6065-78. PMC: 3688272. DOI: 10.1088/0031-9155/54/20/003. View

13.

Shin D, Yoon M, Kwak J, Shin J, Lee S, Park S . Secondary neutron doses for several beam configurations for proton therapy. Int J Radiat Oncol Biol Phys. 2009; 74(1):260-5. DOI: 10.1016/j.ijrobp.2008.10.090. View

14.

Taddei P, Mirkovic D, Fontenot J, Giebeler A, Zheng Y, Kornguth D . Stray radiation dose and second cancer risk for a pediatric patient receiving craniospinal irradiation with proton beams. Phys Med Biol. 2009; 54(8):2259-75. PMC: 4142507. DOI: 10.1088/0031-9155/54/8/001. View

15.

Hall E . Intensity-modulated radiation therapy, protons, and the risk of second cancers. Int J Radiat Oncol Biol Phys. 2006; 65(1):1-7. DOI: 10.1016/j.ijrobp.2006.01.027. View

16.

Schneider U, Agosteo S, Pedroni E, Besserer J . Secondary neutron dose during proton therapy using spot scanning. Int J Radiat Oncol Biol Phys. 2002; 53(1):244-51. DOI: 10.1016/s0360-3016(01)02826-7. View

17.

Agosteo S, Birattari C, Caravaggio M, Silari M, Tosi G . Secondary neutron and photon dose in proton therapy. Radiother Oncol. 1999; 48(3):293-305. DOI: 10.1016/s0167-8140(98)00049-8. View

18.

Schneider U, Lomax A, Lombriser N . Comparative risk assessment of secondary cancer incidence after treatment of Hodgkin's disease with photon and proton radiation. Radiat Res. 2000; 154(4):382-8. DOI: 10.1667/0033-7587(2000)154[0382:craosc]2.0.co;2. View

19.

Egger E, Zografos L, Schalenbourg A, Beati D, Bohringer T, Chamot L . Eye retention after proton beam radiotherapy for uveal melanoma. Int J Radiat Oncol Biol Phys. 2003; 55(4):867-80. DOI: 10.1016/s0360-3016(02)04200-1. View