Biocatalytic Synthesis of Pikromycin, Methymycin, Neomethymycin, Novamethymycin, and Ketomethymycin

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2013 Jul 20

PMID 23866020

Citations 30

Authors

Douglas A Hansen

Christopher M Rath

Eli B Eisman

Alison R H Narayan

Jeffrey D Kittendorf

Jonathan D Mortison

Yeo Joon Yoon

David H Sherman

Affiliations

Soon will be listed here.

Abstract

A biocatalytic platform that employs the final two monomodular type I polyketide synthases of the pikromycin pathway in vitro followed by direct appendage of D-desosamine and final C-H oxidation(s) in vivo was developed and applied toward the synthesis of a suite of 12- and 14-membered ring macrolide natural products. This methodology delivered both compound classes in 13 steps (longest linear sequence) from commercially available (R)-Roche ester in >10% overall yields.

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