Association of CD247 Polymorphisms with Rheumatoid Arthritis: a Replication Study and a Meta-analysis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Jul 18

PMID 23861880

Citations 10

Authors

Maria Teruel

Cushla McKinney

Alejandro Balsa

Dora Pascual-Salcedo

Luis Rodriguez-Rodriguez

Ana M Ortiz

Carmen Gomez-Vaquero

Miguel A Gonzalez-Gay

Malcolm Smith

Torsten Witte

Tony Merriman

Benedicte A Lie

Javier Martin

Affiliations

Soon will be listed here.

Abstract

Given the role of CD247 in the response of the T cells, its entailment in autoimmune diseases and in order to better clarify the role of this gene in RA susceptibility, we aimed to analyze CD247 gene variants previously associated with other autoimmune diseases (rs1052237, rs2056626 and rs864537) in a large independent European Caucasian population. However, no evidence of association was found for the analyzed CD247 single-nucleotide polymorphisms (SNPs) with RA and with the presence/absence of anti-cyclic citrullinated polypeptide. We performed a meta-analysis including previously published GWAS data from the rs864537 variant, revealing an overall genome-wide significant association between this CD247 SNP and RA with anti-CCP (OR = 0.90, CI 95% = 0.87-0.93, Poverall = 2.1×10(-10)). Our results show for first time a GWAS-level association between this CD247 polymorphism and RA risk.

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