Albendazole and Its Derivative JVG9 Induce Encystation on Giardia Intestinalis Trophozoites

Overview

Journal Parasitol Res

Specialty Parasitology

Date 2013 Jul 17

PMID 23857298

Citations 2

Authors

Armando Perez-Rangel

Jose Manuel Hernandez

Araceli Castillo-Romero

Lilian Yepez-Mulia

Rafael Castillo

Francisco Hernandez-Luis

Benjamin Nogueda-Torres

Juan Pedro Luna-Arias

Gerardo Radilla

Gloria Leon-Avila

Affiliations

Soon will be listed here.

Abstract

In the present study, we evaluated the effect of an albendazole (ABZ) derivative JVG9 on cultured Giardia intestinalis. To assess the JVG9 effects, we evaluated the tubulin cytoskeleton by confocal microscopy, and we found that the characteristic staining was modified. The scanning electron microscopy images revealed extremely damaged trophozoites and cyst-like cells. The confocal images revealed that this drug triggered the expression of cyst wall protein 1 and encystation. We also found that at low doses, AL triggered the encystation process too.

Citing Articles

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