Fetal and Infant Growth Predict Hip Geometry at 6 Y Old: Findings from the Southampton Women's Survey

Overview

Journal Pediatr Res

Specialties Biology
Pediatrics

Date 2013 Jul 17

PMID 23857297

Citations 4

Authors

Nicholas C Harvey

Zoe A Cole

Sarah R Crozier

Georgia Ntani

Pamela A Mahon

Sian M Robinson

Hazel M Inskip

Keith M Godfrey

Elaine M Dennison

Cyrus Cooper

Affiliations

Soon will be listed here.

Abstract

Background: We investigated relationships between early growth and proximal femoral geometry at age 6 y in a prospective population-based cohort, the Southampton Women's Survey.

Methods: In 493 mother-offspring pairs, we assessed linear size using high-resolution ultrasound at 11, 19, and 34 wk gestation (femur length) and at birth and 1, 2, 3, 4, and 6 y (crown-heel length/height). SD scores were created and conditional regression modeling generated mutually independent growth variables. Children underwent hip dual-energy X-ray absorptiometry (DXA) at 6 y; hip structure analysis software yielded measures of geometry and strength.

Results: There were strong associations between early linear growth and femoral neck section modulus (Z) at 6 y, with the strongest relationships observed for femur growth from 19 to 34 wk gestation (β = 0.26 cm(3)/SD, P < 0.0001), and for height growth from birth to 1 y (β = 0.25 cm(3)/SD, P < 0.0001) and 1 to 2 y (β = 0.33 cm(3)/SD, P < 0.0001), with progressively weaker relationships over years 3 (β = 0.23 cm(3)/SD, P = 0.0002) and 4 (β = 0.10 cm(3)/SD, P = 0.18).

Conclusion: These results demonstrate that growth before age 3 y predicts proximal femoral geometry at 6 y old. These data suggest critical periods in which there is capacity for long-term influence on the later skeletal growth trajectory.

Citing Articles

Early Life Programming of Skeletal Health.

Moon R, Citeroni N, Aihie R, Harvey N Curr Osteoporos Rep. 2023; 21(4):433-446.

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Bone trait ranking in the population is not established during antenatal growth but is robustly established in the first postnatal year.

Skaren L, Wang X, Bjornerem A PLoS One. 2018; 13(9):e0203945.

PMID: 30222785 PMC: 6141090. DOI: 10.1371/journal.pone.0203945.

Placental Size Is Associated Differentially With Postnatal Bone Size and Density.

Holroyd C, Osmond C, Barker D, Ring S, Lawlor D, Tobias J J Bone Miner Res. 2016; 31(10):1855-1864.

PMID: 26999363 PMC: 5010780. DOI: 10.1002/jbmr.2840.

Longitudinal changes in lean mass predict pQCT measures of tibial geometry and mineralisation at 6-7 years.

Moon R, Cole Z, Crozier S, Curtis E, Davies J, Gregson C Bone. 2015; 75:105-10.

PMID: 25703480 PMC: 4556067. DOI: 10.1016/j.bone.2015.02.015.

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