Stereoselective Binding of Chiral Drugs to Plasma Proteins

Overview

Journal Acta Pharmacol Sin

Specialty Pharmacology

Date 2013 Jul 16

PMID 23852086

Citations 22

Authors

Qi Shen

Lu Wang

Hui Zhou

Hui-di Jiang

Lu-Shan Yu

Su Zeng

Affiliations

Soon will be listed here.

Abstract

Chiral drugs show distinct biochemical and pharmacological behaviors in the human body. The binding of chiral drugs to plasma proteins usually exhibits stereoselectivity, which has a far-reaching influence on their pharmacological activities and pharmacokinetic profiles. In this review, the stereoselective binding of chiral drugs to human serum albumin (HSA), α1-acid glycoprotein (AGP) and lipoprotein, three most important proteins in human plasma, are detailed. Furthermore, the application of AGP variants and recombinant fragments of HSA for studying enantiomer binding properties is also discussed. Apart from the stereoselectivity of enantiomer-protein binding, enantiomer-enantiomer interactions that may induce allosteric effects are also described. Additionally, the techniques and methods used to determine drug-protein binding parameters are briefly reviewed.

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