The Effects of Diet, Lipolysis and Limb Ischaemia on the Distribution of Plasma Tryptophan in the Rat

Overview

Journal Biochem J

Specialty Biochemistry

Date 1975 Mar 1

PMID 238505

Citations 6

Authors

H B STONER

V J Cunningham

P M Elson

A Hunt

Affiliations

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Abstract

A non-linear relationship between the plasma non-esterified fatty acid concentration and the percentage of free plasma tryptophan was found in rats in different nutritional states, although non-esterified fatty acids are not the only factors determining the percentage of free tryptophan. This relationship was not seen in rats injured by limb ischaemia. The effect of drugs causing rapid increases in the plasma non-esterified fatty acid concentration was also studied. Isoprenaline decreased the total plasma tryptophan concentration. Dichloroisoprenaline caused a sustained increase in the plasma non-esterified fatty acid concentration which was accompanied by an increase in the concentration of free plasma tryptophan and followed by a fall in the concentration of total tryptophan. The loss of tryptophan from the plasma was attributed to an altered distribution of tryptophan in the extracellular space rather than to increased metabolism. This interpretation was supported by determinations of the irreversible disposal rate of plasma tryptophan which in uninjured rats was unaffected by the concentration of free plasma tryptophan. In the injured rats this rate was unaltered during limb ischaemia but was decreased after removal of the tourniquets; increased competition for tissue entry by other neutral amino acids and the fall in body temperature could be factors in this fall.

Citing Articles

Learning Deficits Induced by High-Calorie Feeding in the Rat are Associated With Impaired Brain Kynurenine Pathway Metabolism.

Mezo-Gonzalez C, Daher Abdi A, Reyes-Castro L, Olvera Hernandez S, Almeida C, Croyal M Int J Tryptophan Res. 2022; 15:11786469221111116.

PMID: 35846874 PMC: 9277427. DOI: 10.1177/11786469221111116.

Studies on the mechanism of shock. Central serotoninergic neuron activity after trauma in the rat.

STONER H, Hunt A, Hadfield J, MARSHALL H Br J Exp Pathol. 1980; 61(1):61-8.

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Isoprenaline increases brain concentrations of administered L-dopa and L-tryptophan in the rat.

Eriksson T, Carlsson A Psychopharmacology (Berl). 1982; 77(1):98-100.

PMID: 6812125 DOI: 10.1007/BF00436106.

Peripheral and central short-term effects of fusaric acid, a DBH inhibitor, on tryptophan and serotonin metabolism in the rat.

Chaouloff F, Laude D, Merino D, Serrurrier B, Elghozi J J Neural Transm. 1986; 65(3-4):219-32.

PMID: 2423643 DOI: 10.1007/BF01249084.

The binding of L-tryptophan to serum albumins in the presence of non-esterified fatty acids.

Cunningham V, Hay L, STONER H Biochem J. 1975; 146(3):653-8.

PMID: 1147909 PMC: 1165355. DOI: 10.1042/bj1460653.

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