Oesophagostomum Dentatum Extract Modulates T Cell-dependent Immune Responses to Bystander Antigens and Prevents the Development of Allergy in Mice

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2013 Jul 12

PMID 23844022

Citations 19

Authors

Irma Schabussova

Onisa Ul-Haq

Elisabeth Hoflehner

Johnnie Akgun

Angelika Wagner

Gerhard Loupal

Anja Joachim

Barbel Ruttkowski

Rick M Maizels

Ursula Wiedermann

Affiliations

Soon will be listed here.

Abstract

One third of the human population is currently infected by one or more species of parasitic helminths. Certain helminths establish long-term chronic infections resulting in a modulation of the host's immune system with attenuated responsiveness to "bystander" antigens such as allergens or vaccines. In this study we investigated whether parasite-derived products suppress the development of allergic inflammation in a mouse model. We show that extract derived from adult male Oesophagostomum dentatum (eMOD) induced Th2 and regulatory responses in BALB/c mice. Stimulation of bone marrow-derived dendritic cells induced production of regulatory cytokines IL-10 and TGF-beta. In a mouse model of birch pollen allergy, co-administration of eMOD with sensitizing allergen Bet v 1 markedly reduced the production of allergen-specific antibodies in serum as well as IgE-dependent basophil degranulation. Furthermore, eMOD prevented the development of airway inflammation, as demonstrated by attenuation of bronchoalveolar lavages eosinophil influx, peribronchial inflammatory infiltrate, and mucus secretion in lungs and IL-4 and IL-5 levels in lung cell cultures. Reduced secretion of Th2-related cytokines by birch pollen-re-stimulated splenocytes and mesenteric lymph node cells was observed in eMOD-treated/sensitized and challenged mice in comparison to sensitized and challenged controls. The suppressive effects of eMOD were heat-stable. Immunization with model antigens in the presence of eMOD reduced production of antibodies to thymus-dependent but not to thymus-independent antigen, suggesting that suppression of the immune responses by eMOD was mediated by interference with antigen presenting cell or T helper cell function but did not directly suppress B cell function. In conclusion, we have shown that eMOD possesses immunomodulatory properties and that heat-stable factors in eMOD are responsible for the dramatic suppression of allergic responses in a mouse model of type I allergy. The identification and characterization of parasite-derived immune-modulating molecules might have potential for designing novel prophylactic/therapeutic strategies for immune-mediated diseases.

Citing Articles

Editorial: "You shall not pass" or "Let`s make a deal" - crosstalk between helminths and the host immune system.

Baska P, Schabussova I, Zawistowska-Deniziak A Front Cell Infect Microbiol. 2023; 13:1244429.

PMID: 37520436 PMC: 10381937. DOI: 10.3389/fcimb.2023.1244429.

Nematode Orthologs of Macrophage Migration Inhibitory Factor (MIF) as Modulators of the Host Immune Response and Potential Therapeutic Targets.

Karabowicz J, Dlugosz E, Baska P, Wisniewski M Pathogens. 2022; 11(2).

PMID: 35215200 PMC: 8877345. DOI: 10.3390/pathogens11020258.

Reduction of Allergic Lung Disease by Mucosal Application of -Derived Molecules: Possible Role of Carbohydrates.

Korb E, Drinic M, Wagner A, Geissler N, Inic-Kanada A, Peschke R Front Immunol. 2021; 11:612766.

PMID: 33776987 PMC: 7988086. DOI: 10.3389/fimmu.2020.612766.

Schistosoma japonicum peptide SJMHE1 suppresses airway inflammation of allergic asthma in mice.

Zhang W, Li L, Zheng Y, Xue F, Yu M, Ma Y J Cell Mol Med. 2019; 23(11):7819-7829.

PMID: 31496071 PMC: 6815837. DOI: 10.1111/jcmm.14661.

DNA and mRNA vaccination against allergies.

Scheiblhofer S, Thalhamer J, Weiss R Pediatr Allergy Immunol. 2018; 29(7):679-688.

PMID: 30063806 PMC: 6283005. DOI: 10.1111/pai.12964.

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