Naphthyridinomycin Biosynthesis Revealing the Use of Leader Peptide to Guide Nonribosomal Peptide Assembly

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2013 Jul 12

PMID 23841701

Citations 13

Authors

Jin-Yue Pu

Chao Peng

Man-Cheng Tang

Yue Zhang

Jian-Ping Guo

Li-Qiang Song

Qiang Hua

Gong-Li Tang

Affiliations

Soon will be listed here.

Abstract

Analysis of naphthyridinomycin gene cluster revealed that this antibiotic is generated by nonribosomal peptide synthetase (NRPS) machinery. However, four modules encoded by two genes do not correspond with the structural units in the final product. Genetic and biochemical characterization of the gene cluster suggested that the leader peptide mechanism for the NRPS assembly line was involved in biosynthesis of this tetrahydroisoquinoline alkaloid.

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