Penile Calciphylaxis in End Stage Renal Disease

Overview

Journal Case Rep Urol

Publisher Wiley

Specialty Urology

Date 2013 Jul 11

PMID 23841013

Citations 4

Authors

Vincenzo Barbera

Luca Di Lullo

Antonio Gorini

Giovanni Otranto

Fulvio Floccari

Moreno Malaguti

Alberto Santoboni

Affiliations

Soon will be listed here.

Abstract

Calciphylaxis, better described as "Calcific uremic arteriolopathy" (CUA), involves about 1-4% of hemodialysis patients all around the world with high mortality rates. We describe a rare clinical case of CUA in peritoneal dialysis patient associated with urological disease. Penile calciphylaxis represents rare clinical complication, and an early diagnosis and multidisciplinary approach are requested. Pathogenesis is still unclear, and therapeutic approaches need more long-term clinical trials to test their efficacy and safety.

Citing Articles

Risk factors, treatment modalities, and clinical outcomes of penile calciphylaxis: systematic review.

Wipattanakitcharoen A, Takkavatakarn K, Susantitaphong P World J Urol. 2023; 41(11):2959-2966.

PMID: 37782324 DOI: 10.1007/s00345-023-04611-9.

Early onset calciphylaxis following acute kidney injury secondary to anti-glomerular basement membrane antibody disease.

Shahzad S, Alfaris F, Arslan M, Mehta S BMJ Case Rep. 2021; 14(4).

PMID: 33827879 PMC: 8030672. DOI: 10.1136/bcr-2020-241265.

Penile gangrene due to calciphylaxis: a multidisciplinary approach to a complex clinical challenge.

David R, Nowicki J, Lee J, Dean N BMJ Case Rep. 2019; 12(12).

PMID: 31811092 PMC: 6904196. DOI: 10.1136/bcr-2019-232138.

Penile Calciphylaxis in a Patient with End-stage Renal Disease: A Case Report and Review of the Literature.

Yang T, Wang T, Chen M, Sun F, Chiu A, Chen Y Open Med (Wars). 2018; 13:158-163.

PMID: 29756051 PMC: 5941707. DOI: 10.1515/med-2018-0025.

References

Banerjee C, Woller S, Holm J, Stevens S, Lahey M . Atypical calciphylaxis in a patient receiving warfarin then resolving with cessation of warfarin and application of hyperbaric oxygen therapy. Clin Appl Thromb Hemost. 2009; 16(3):345-50. DOI: 10.1177/1076029609355588. View

Hayden M, Goldsmith D . Sodium thiosulfate: new hope for the treatment of calciphylaxis. Semin Dial. 2010; 23(3):258-62. DOI: 10.1111/j.1525-139X.2010.00738.x. View

Ross E . Evolution of treatment strategies for calciphylaxis. Am J Nephrol. 2011; 34(5):460-7. DOI: 10.1159/000332221. View

Wilmer W, Magro C . Calciphylaxis: emerging concepts in prevention, diagnosis, and treatment. Semin Dial. 2002; 15(3):172-86. DOI: 10.1046/j.1525-139x.2002.00052.x. View

Tamura M, Hiroshige K, Osajima A, Soejima M, Takasugi M, Kuroiwa A . A dialysis patient with systemic calciphylaxis exhibiting rapidly progressive visceral ischemia and acral gangrene. Intern Med. 1995; 34(9):908-12. DOI: 10.2169/internalmedicine.34.908. View

Fine A, Zacharias J . Calciphylaxis is usually non-ulcerating: risk factors, outcome and therapy. Kidney Int. 2002; 61(6):2210-7. DOI: 10.1046/j.1523-1755.2002.00375.x. View

Franks Jr A . Skin manifestations of internal disease. Med Clin North Am. 2009; 93(6):1265-82. DOI: 10.1016/j.mcna.2009.08.010. View

Mazzaferro S, Pasquali M, Cozzolino M . Treatment of cardiovascular calcification in uremia. Curr Vasc Pharmacol. 2011; 9(6):741-9. DOI: 10.2174/157016111797484161. View

Kakagia D, Kriki P, Thodis E, Roumeliotis A, Vargemezis V . Calcific uremic arteriolopathy treated with cinacalcet, paricalcitol, and autologous growth factors. J Cutan Med Surg. 2011; 15(2):121-4. DOI: 10.2310/7750.2011.10052. View

10.

Angelis M, Wong L, Myers S, Wong L . Calciphylaxis in patients on hemodialysis: a prevalence study. Surgery. 1998; 122(6):1083-9; discussion 1089-90. DOI: 10.1016/s0039-6060(97)90212-9. View

11.

Weenig R, Sewell L, Davis M, McCarthy J, Pittelkow M . Calciphylaxis: natural history, risk factor analysis, and outcome. J Am Acad Dermatol. 2006; 56(4):569-79. DOI: 10.1016/j.jaad.2006.08.065. View