Shaping the Nervous System: Role of the Core Planar Cell Polarity Genes

Overview

Journal Nat Rev Neurosci

Specialty Neurology

Date 2013 Jul 11

PMID 23839596

Citations 70

Authors

Fadel Tissir

Andre M Goffinet

Affiliations

Soon will be listed here.

Abstract

Planar cell polarity (PCP) is complementary to the intrinsic polarization of single cells and refers to the global coordination of cell behaviour in the plane of a tissue and, by extension, to the signalling pathways that control it. PCP is most evident in cell sheets, and research into PCP was for years confined to studies in Drosophila melanogaster. However, PCP has more recently emerged as an important phenomenon in vertebrates, in which it regulates various developmental processes and is associated with multiple disorders. In particular, core PCP genes are crucial for the development and function of the nervous system. They are involved in neural tube closure, ependymal polarity, neuronal migration, dendritic growth and axon guidance.

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