Memory T Cells in Transplantation - Progress and Challenges

Overview

Journal Curr Opin Organ Transplant

Specialty General Surgery

Date 2013 Jul 11

PMID 23838642

Citations 14

Authors

Xian C Li

Malgosia Kloc

Rafik M Ghobrial

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Memory T cells present a different set of challenges to transplant patients; they are needed for protection against invading pathogens, especially under conditions of immunosuppression. But their presence also threatens transplant survival, as some of them are alloreactive. Efforts to resolve this paradox will be critical in the induction of transplant tolerance.

Recent Findings: There has been significant progress made in the past few years in the areas of population diversity of memory T cells, metabolic control of their induction, and mechanisms and pathways involved in memory cell exhaustion. Multiple targets on memory T cells have been identified, some of which are under vigorous testing in various transplant models.

Summary: Memory T cells are both friends and foes to transplant patients, and tolerance strategies should selectively target alloreactive memory T cells and leave other memory cells unaltered. This situation remains a major challenge in the clinic.

Citing Articles

Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation.

Sun Y, Sen S, Parmar R, Arakawa-Hoyt J, Cappelletti M, Rossetti M Front Immunol. 2025; 16:1542531.

PMID: 40028342 PMC: 11868092. DOI: 10.3389/fimmu.2025.1542531.

Immunogenicity and tolerance induction in vascularized composite allotransplantation.

Sun J, Adil A, Biniazan F, Haykal S Front Transplant. 2024; 3:1350546.

PMID: 38993748 PMC: 11235364. DOI: 10.3389/frtra.2024.1350546.

Cellular activation pathways and interaction networks in vascularized composite allotransplantation.

Knoedler L, Knoedler S, Panayi A, Lee C, Sadigh S, Huelsboemer L Front Immunol. 2023; 14:1179355.

PMID: 37266446 PMC: 10230044. DOI: 10.3389/fimmu.2023.1179355.

Integrated analysis of an in vivo model of intra-nasal exposure to instilled air pollutants reveals cell-type specific responses in the placenta.

Tosevska A, Ghosh S, Ganguly A, Cappelletti M, Kallapur S, Pellegrini M Sci Rep. 2022; 12(1):8438.

PMID: 35589747 PMC: 9119931. DOI: 10.1038/s41598-022-12340-z.

Allogeneic ADSCs Induce the Production of Alloreactive Memory-CD8 T Cells through HLA-ABC Antigens.

Chang S, Kim H, Park C Cells. 2020; 9(5).

PMID: 32443511 PMC: 7290988. DOI: 10.3390/cells9051246.

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