» Articles » PMID: 23835731

Molecular Pathogenesis of Hepatic Adenomas and Its Implications for Surgical Management

Overview
Specialty Gastroenterology
Date 2013 Jul 10
PMID 23835731
Citations 17
Authors
Affiliations
Soon will be listed here.
Abstract

Introduction: Hepatic adenomas (HAs) are benign tumors of the liver, which can be solitary or multiple, and have a definite risk of malignant degeneration.

Discussion: The pathogenesis and natural history of this disease entity were previously unknown. Recent research into the molecular pathogenesis of this condition has provided evidence for the malignant transformation of some of these adenomas. In the current article, we discuss the current evidence on the molecular biology underlying malignant transformation of hepatic adenomas and the implications for the surgical management of this disease.

Citing Articles

Alpha-fetoprotein: Past, present, and future.

Yeo Y, Lee Y, Tseng H, Zhu Y, You S, Agopian V Hepatol Commun. 2024; 8(5).

PMID: 38619448 PMC: 11019827. DOI: 10.1097/HC9.0000000000000422.


Hepatocellular Neoplasm of Uncertain Potential of Malignancy or Well-Differentiated Hepatocellular Carcinoma Arising within Hepatocellular Adenoma.

Campos E, Silva R, Rodrigues S, de Almeida M, Lopes J, Aral M Case Rep Surg. 2023; 2023:2831510.

PMID: 37427296 PMC: 10328728. DOI: 10.1155/2023/2831510.


Living Donor Liver Transplantation as a Backup Procedure: Treatment Strategy for Hepatocellular Adenomas Requiring Complex Resections.

Fonseca E, Feier F, Vincenzi R, Candido H, Azambuja R, Payao F Case Rep Surg. 2022; 2022:1015061.

PMID: 35223125 PMC: 8872689. DOI: 10.1155/2022/1015061.


Hepatocellular carcinoma arising from hepatic adenoma in a young woman.

Yacoub H, Kchir H, Cherif D, Hassine H, Haouet S, Ayari A Clin Case Rep. 2020; 8(9):1659-1662.

PMID: 32983471 PMC: 7495806. DOI: 10.1002/ccr3.2975.


A rare case of hepatocellular carcinoma arising from gadoxetate-retaining hepatic adenoma.

Cedillo M, Wong J, Song J, Liao J Radiol Case Rep. 2019; 15(2):141-143.

PMID: 31827660 PMC: 6889246. DOI: 10.1016/j.radcr.2019.10.030.


References
1.
Micchelli S, Vivekanandan P, Boitnott J, Pawlik T, Choti M, Torbenson M . Malignant transformation of hepatic adenomas. Mod Pathol. 2008; 21(4):491-7. DOI: 10.1038/modpathol.2008.8. View

2.
Bellamy C, Maxwell R, Prost S, Azodo I, Powell J, Manning J . The value of immunophenotyping hepatocellular adenomas: consecutive resections at one UK centre. Histopathology. 2012; 62(3):431-45. DOI: 10.1111/his.12011. View

3.
Chen Y, Jeng Y, Yeh S, Chen P . P53 gene and Wnt signaling in benign neoplasms: beta-catenin mutations in hepatic adenoma but not in focal nodular hyperplasia. Hepatology. 2002; 36(4 Pt 1):927-35. DOI: 10.1053/jhep.2002.36126. View

4.
Stoot J, Coelen R, Jong M, Dejong C . Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than 1600 adenoma cases. HPB (Oxford). 2010; 12(8):509-22. PMC: 2997656. DOI: 10.1111/j.1477-2574.2010.00222.x. View

5.
Reddy K, Kligerman S, Levi J, Livingstone A, Molina E, Franceschi D . Benign and solid tumors of the liver: relationship to sex, age, size of tumors, and outcome. Am Surg. 2001; 67(2):173-8. View