Biological Monitoring of Foundry Workers Exposed to Polycyclic Aromatic Hydrocarbons

Overview

Journal Br J Ind Med

Specialty Occupational Medicine

Date 1990 Jul 1

PMID 2383513

Citations 17

Authors

D Sherson

P Sabro

T Sigsgaard

F JOHANSEN

H Autrup

Affiliations

Soon will be listed here.

Abstract

This investigation describes benzo(a)pyrene (BP) serum protein adduct concentrations in 45 foundry workers and 45 matched non-occupationally exposed controls. High and low BP exposure groups were defined using breathing zone hygienic samples for both quartz and BP exposures. A newly developed enzyme linked immunosorbent assay detected benzo(a)pyrenediolepoxide-I binding to serum protein. Mean BP protein adduct concentrations (SD) for non-smoking (24.0 BP equivalents/100 micrograms protein (21.0] and smoking (28.0 (18.2] foundry workers were significantly higher than mean values for non-smoking (7.23 (8.72] and smoking (14.2 (24.4] controls. Foundry workers with high exposures to either quartz (28.4 (15.5] or BP (30.7 (19.3] had slightly raised mean adduct concentrations compared with foundry workers with low exposure for quartz (23.9 (23.1] or BP (24.5 (19.4). Highest mean adduct concentrations were found among a small group of workers with simultaneous high exposures to both quartz and BP (39.2 (6.5] suggesting an additive effect. These data support the ideas of a possible aetiological connection between an increased risk of lung cancer and BP exposure among foundry workers, and an additive effect between BP and quartz. Measurement of BP serum protein adduct concentrations appears to be a useful method by which groups exposed to BP may be biologically monitored.

Citing Articles

A sandwich ELISA for measuring benzo[a]pyrene-albumin adducts in human plasma.

Chung M, Regazzoni L, McClean M, Herrick R, Rappaport S Anal Biochem. 2013; 435(2):140-9.

PMID: 23333225 PMC: 6354764. DOI: 10.1016/j.ab.2012.12.021.

A sandwich enzyme-linked immunosorbent assay for adducts of polycyclic aromatic hydrocarbons with human serum albumin.

Chung M, Riby J, Li H, Iavarone A, Williams E, Zheng Y Anal Biochem. 2010; 400(1):123-9.

PMID: 20083082 PMC: 2842209. DOI: 10.1016/j.ab.2010.01.018.

Association between plasma BPDE-Alb adduct concentrations and DNA damage of peripheral blood lymphocytes among coke oven workers.

Wang H, Chen W, Zheng H, Guo L, Liang H, Yang X Occup Environ Med. 2007; 64(11):753-8.

PMID: 17449561 PMC: 2078419. DOI: 10.1136/oem.2006.030445.

Risk of bladder cancer in foundry workers: a meta-analysis.

Gaertner R, Theriault G Occup Environ Med. 2002; 59(10):655-63.

PMID: 12356924 PMC: 1740225. DOI: 10.1136/oem.59.10.655.

Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air.

Gerde P, Hanberg A, Jernstrom B, Johansson C, Kyrklund T, Rannug A Environ Health Perspect. 2002; 110 Suppl 3:451-88.

PMID: 12060843 PMC: 1241197. DOI: 10.1289/ehp.110-1241197.

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