To Dream the Impossible Dream: Universal Influenza Vaccination

Overview

Journal Curr Opin Virol

Publisher Elsevier

Specialty Microbiology

Date 2013 Jul 10

PMID 23835048

Citations 17

Authors

Jonathan W Yewdell

Affiliations

Soon will be listed here.

Abstract

Year in and year out, influenza viruses exact a deadly and expensive toll on humanity. Current vaccines simply do not keep pace with viral immune evasion, providing partial protection, at best, among various age groups. A quantum leap in understanding the basic principles of the adaptive and innate immune responses to influenza viruses offers the opportunity to develop vaccines that forestall, and potentially ultimately defeat, influenza virus antigenic variation.

Citing Articles

Assessing the Intense Influenza A(H1N1)pdm09 Epidemic and Vaccine Effectiveness in the Post-COVID Season in the Russian Federation.

Sominina A, Danilenko D, Komissarov A, Pisareva M, Fadeev A, Konovalova N Viruses. 2023; 15(8).

PMID: 37632122 PMC: 10458445. DOI: 10.3390/v15081780.

Surfactant protein A alters endosomal trafficking of influenza A virus in macrophages.

Yau E, Yang L, Chen Y, Umstead T, Atkins H, Katz Z Front Immunol. 2023; 14:919800.

PMID: 36960051 PMC: 10028185. DOI: 10.3389/fimmu.2023.919800.

Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies.

Phillips A, Lawrence K, Moulana A, Dupic T, Chang J, Johnson M Elife. 2021; 10.

PMID: 34491198 PMC: 8476123. DOI: 10.7554/eLife.71393.

Antigenic Variability.

Mosa A Front Immunol. 2020; 11:2057.

PMID: 33013870 PMC: 7516049. DOI: 10.3389/fimmu.2020.02057.

Comparison of the Protective Efficacy of Neutralizing Epitopes of 2009 Pandemic H1N1 Influenza Hemagglutinin.

Peng B, Peng N, Zhang Y, Zhang F, Li X, Chang H Front Immunol. 2017; 8:1070.

PMID: 28912784 PMC: 5583165. DOI: 10.3389/fimmu.2017.01070.

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