7-Aza-des-A-steroids with Antimicrobial and Cytotoxic Activity

Overview

Journal Sci Pharm

Publisher MDPI

Specialty Pharmacology

Date 2013 Jul 9

PMID 23833707

Citations 2

Authors

Melanie Krojer

Marco Keller

Franz Bracher

Affiliations

Soon will be listed here.

Abstract

This paper describes a convenient approach to the 7-aza-des-A-steroid (6,6a,7,8,9,9a-hexahydro-5H-cyclopenta[h]quinoline) scaffold starting from Grundmann's ketone using two different pyridine annulation protocols. The biological evaluation of the pyridine and pyridinium products revealed that these compounds unexpectedly do not interfere with ergosterol and cholesterol biosynthesis. The pyridinium compound 6 showed significant antimicrobial and cytotoxic activities which are most likely due to its detergent-like structure.

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