Typical Fibrolamellar Hepatocellular Carcinoma in a Japanese Boy: Report of a Case

Overview

Journal Surg Today

Specialty General Surgery

Date 2013 Jul 6

PMID 23828653

Citations 4

Authors

Masanori Matsuda

Hidetake Amemiya

Hiromichi Kawaida

Hirotaka Okamoto

Naohiro Hosomura

Masami Asakawa

Katsuhiro Sano

Utaroh Motosugi

Tomoaki Ichikawa

Tadao Nakazawa

Hideki Fujii

Affiliations

Soon will be listed here.

Abstract

We report a case of typical fibrolamellar hepatocellular carcinoma (FL-HCC) in a 16-year-old Japanese boy. This is very rare malignancy in Japan. The patient was referred for investigation of a large hepatic tumor and the results of tests for hepatitis B virus surface antigen and hepatitis C virus antibody were negative. Liver function test results and serum alpha-fetoprotein (AFP) levels were normal; however, the prothrombin induced by vitamin K absence/antagonist II was elevated. Computed tomography (CT) showed a large lobulated heterogeneously enhanced tumor in the posterior section of the liver. We diagnosed FL-HCC and performed posterior sectionectomy of the liver. The resected specimen contained a light brown and green tumor with a central fibrous scar, 10.0 cm in diameter. Microscopic and electron microscopic examinations revealed the typical features of FL-HCC. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, but negative for CK19 and AFP. The patient was alive without recurrence 48 months after surgery. Following this case report, we summarize the clinical features of the Japanese cases documented in the literature.

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