MicroRNA in Alzheimer's Disease: an Exploratory Study in Brain, Cerebrospinal Fluid and Plasma

Overview

Journal Biomarkers

Specialty Biochemistry

Date 2013 Jul 5

PMID 23822153

Citations 58

Authors

Lynn M Bekris

Franziska Lutz

Thomas J Montine

Chang En Yu

Debby Tsuang

Elaine R Peskind

James B Leverenz

Affiliations

Soon will be listed here.

Abstract

MicroRNA (miRNA) may be potential biomarkers of Alzheimer's disease (AD). The objective of this investigation was to demonstrate that miRNAs in human brain or biofluids are differentially expressed according to disease status, tissue type, neuritic plaque score or Braak stage. Post-mortem brain (PMB) miRNA were profiled using arrays and validated using quantitative RT-PCR (qRT-PCR). Five qRT-PCR-validated miRNAs were measured in an independent sample of PMB, cerebrospinal fluid and plasma from the same subjects. Plasma miR-15a was found to be associated with plaque score in the independent sample. In conclusion, miRNA present in human biofluids may offer utility as biomarkers of AD.

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