Factors Related to Fungiform Papillae Density: the Beaver Dam Offspring Study

Overview

Journal Chem Senses

Publisher Oxford University Press

Specialty Biochemistry

Date 2013 Jul 4

PMID 23821729

Citations 40

Authors

Mary E Fischer

Karen J Cruickshanks

Carla R Schubert

Alex Pinto

Ronald Klein

Nathan Pankratz

James S Pankow

Guan-Hua Huang

Affiliations

Soon will be listed here.

Abstract

The distribution of fungiform papillae density and associated factors were examined in the Beaver Dam Offspring Study. Data were from 2371 participants (mean age = 48.8 years, range = 21-84 years) with 1108 males and 1263 females. Fungiform papillae were highlighted with blue food coloring and the number of fungiform papillae within a standard 6-mm circle was counted. Whole mouth suprathreshold taste intensity was measured. The mean fungiform papillae density was 103.5 papillae/cm(2) (range = 0-212.2 papillae/cm(2)). For each 5-year increase in age, the mean fungiform papillae density was 2.8 papillae/cm(2) lower and the mean density for males was 10.2 papillae/cm(2) lower than for females. Smokers had significantly lower mean densities (former smokers: -5.1 papillae/cm(2); current smokers: -9.3 papillae/cm(2)) than nonsmokers, and heavy alcohol drinkers had a mean density that was 4.7 papillae/cm(2) lower than nonheavy drinkers. Solvent exposure was related to a significantly higher density (+6.8 papillae/cm(2)). The heritability estimate for fungiform papillae density was 40.2%. Propylthiouracil taster status, TAS2R38 haplotype, and perceived taste intensity were not related to density. In summary, wide variability in fungiform papillae density was observed and a number of related factors were found including the modifiable factors of smoking and alcohol consumption.

Citing Articles

Contributions and future potential of animal models for geroscience research on sensory systems.

Fernandes A, Poirier A, Veilleux C, Melin A Geroscience. 2024; 47(1):61-83.

PMID: 39312151 PMC: 11872837. DOI: 10.1007/s11357-024-01327-5.

Investigation of the fungiform papillae number in children with tooth number anomalies.

Alp B, Kalaoglu E, Mentes A Clin Oral Investig. 2024; 28(5):297.

PMID: 38700604 PMC: 11068673. DOI: 10.1007/s00784-024-05696-1.

Does presbygeusia really exist? An updated narrative review.

Ponzo V, Bo M, Favaro E, Merlo F, Isaia G, Presta R Aging Clin Exp Res. 2024; 36(1):84.

PMID: 38558357 PMC: 10984891. DOI: 10.1007/s40520-024-02739-1.

Machine learning and topological data analysis identify unique features of human papillae in 3D scans.

Andreeva R, Sarkar A, Sarkar R Sci Rep. 2023; 13(1):21529.

PMID: 38097616 PMC: 10721919. DOI: 10.1038/s41598-023-46535-9.

Examining the Association between Cigarette Smoking Quantity and Subjective Salt Taste Preference and Salt-Related Eating Behavior.

Ma J, Lee Y Korean J Fam Med. 2023; 44(6):335-341.

PMID: 37647943 PMC: 10667072. DOI: 10.4082/kjfm.23.0027.

References

Koponen A, Seilonen A . Quantitative study of human fungiform papillae and taste buds: variation with aging and in different morphological forms of the tongue. Gerodontics. 1987; 3(3):131-5. View

Zuniga J, Chen N, Phillips C . Chemosensory and somatosensory regeneration after lingual nerve repair in humans. J Oral Maxillofac Surg. 1997; 55(1):2-13; discussion 13-4. DOI: 10.1016/s0278-2391(97)90434-1. View

Duffy V . Variation in oral sensation: implications for diet and health. Curr Opin Gastroenterol. 2007; 23(2):171-7. DOI: 10.1097/MOG.0b013e3280147d50. View

Tepper B, Nurse R . Fat perception is related to PROP taster status. Physiol Behav. 1997; 61(6):949-54. DOI: 10.1016/s0031-9384(96)00608-7. View

Zhang G, Zhang H, Wang X, Zhan Y, Deng S, Qin Y . The relationship between fungiform papillae density and detection threshold for sucrose in the young males. Chem Senses. 2008; 34(1):93-9. DOI: 10.1093/chemse/bjn059. View

Raynor L, Pankow J, Cruickshanks K, Schubert C, Miller M, Klein R . Familial aggregation of olfactory impairment and odor identification in older adults. Laryngoscope. 2010; 120(8):1614-8. PMC: 2998196. DOI: 10.1002/lary.20989. View

Duffy V, Peterson J, Bartoshuk L . Associations between taste genetics, oral sensation and alcohol intake. Physiol Behav. 2004; 82(2-3):435-45. DOI: 10.1016/j.physbeh.2004.04.060. View

Konstantinidis I, Chatziavramidis A, Printza A, Metaxas S, Constantinidis J . Effects of smoking on taste: assessment with contact endoscopy and taste strips. Laryngoscope. 2010; 120(10):1958-63. DOI: 10.1002/lary.21098. View

Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira M, Bender D . PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007; 81(3):559-75. PMC: 1950838. DOI: 10.1086/519795. View

10.

Yackinous C, Guinard J . Relation between PROP taster status and fat perception, touch, and olfaction. Physiol Behav. 2001; 72(3):427-37. DOI: 10.1016/s0031-9384(00)00430-3. View

11.

Nagato T, Matsumoto K, Tanioka H, Kodama J, Toh H . Effect of denervation on morphogenesis of the rat fungiform papilla. Acta Anat (Basel). 1995; 153(4):301-9. DOI: 10.1159/000147739. View

12.

Shahbake M, Hutchinson I, Laing D, Jinks A . Rapid quantitative assessment of fungiform papillae density in the human tongue. Brain Res. 2005; 1052(2):196-201. DOI: 10.1016/j.brainres.2005.06.031. View

13.

Miller Jr I . Variation in human fungiform taste bud densities among regions and subjects. Anat Rec. 1986; 216(4):474-82. DOI: 10.1002/ar.1092160404. View

14.

Duffy V, Davidson A, Kidd J, Kidd K, Speed W, Pakstis A . Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcohol Clin Exp Res. 2004; 28(11):1629-37. PMC: 1397913. DOI: 10.1097/01.alc.0000145789.55183.d4. View

15.

Almasy L, Blangero J . Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet. 1998; 62(5):1198-211. PMC: 1377101. DOI: 10.1086/301844. View

16.

Keating B, Tischfield S, Murray S, Bhangale T, Price T, Glessner J . Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One. 2008; 3(10):e3583. PMC: 2571995. DOI: 10.1371/journal.pone.0003583. View

17.

Cruickshanks K, Schubert C, Snyder D, Bartoshuk L, Huang G, Klein B . Measuring taste impairment in epidemiologic studies: the Beaver Dam Offspring Study. Ann N Y Acad Sci. 2009; 1170:543-52. PMC: 2729771. DOI: 10.1111/j.1749-6632.2009.04103.x. View

18.

Bartoshuk L, Duffy V, Green B, Hoffman H, Ko C, Lucchina L . Valid across-group comparisons with labeled scales: the gLMS versus magnitude matching. Physiol Behav. 2004; 82(1):109-14. DOI: 10.1016/j.physbeh.2004.02.033. View

19.

Schubert C, Cruickshanks K, Fischer M, Huang G, Klein B, Klein R . Olfactory impairment in an adult population: the Beaver Dam Offspring Study. Chem Senses. 2011; 37(4):325-34. PMC: 3325763. DOI: 10.1093/chemse/bjr102. View

20.

Hayes J, Duffy V . Oral sensory phenotype identifies level of sugar and fat required for maximal liking. Physiol Behav. 2008; 95(1-2):77-87. PMC: 2564984. DOI: 10.1016/j.physbeh.2008.04.023. View