Perceptual Judgements and Chronic Imaging of Altered Odour Maps Indicate Comprehensive Stimulus Template Matching in Olfaction

Overview

Journal Nat Commun

Specialty Biology

Date 2013 Jul 4

PMID 23820818

Citations 6

Authors

Edward F Bracey

Bruno Pichler

Andreas T Schaefer

Damian J Wallace

Troy W Margrie

Affiliations

Soon will be listed here.

Abstract

Lesion experiments suggest that odour input to the olfactory bulb contains significant redundant signal such that rodents can discern odours using minimal stimulus-related information. Here we investigate the dependence of odour-quality perception on the integrity of glomerular activity by comparing odour-evoked activity maps before and after epithelial lesions. Lesions prevent mice from recognizing previously experienced odours and differentially delay discrimination learning of unrecognized and novel odour pairs. Poor recognition results not from mice experiencing an altered concentration of an odour but from perception of apparent novel qualities. Consistent with this, relative intensity of glomerular activity following lesions is altered compared with maps recorded in shams and by varying odour concentration. Together, these data show that odour recognition relies on comprehensively matching input patterns to a previously generated stimulus template. When encountering novel odours, access to all glomerular activity ensures rapid generation of new templates to perform accurate perceptual judgements.

Citing Articles

Distinct ACC Neural Mechanisms Underlie Authentic and Transmitted Anxiety Induced by Maternal Separation in Mice.

Jiang J, Tan S, Feng X, Peng Y, Long C, Yang L J Neurosci. 2023; 43(48):8201-8218.

PMID: 37845036 PMC: 10697407. DOI: 10.1523/JNEUROSCI.0558-23.2023.

AutonoMouse: High throughput operant conditioning reveals progressive impairment with graded olfactory bulb lesions.

Erskine A, Bus T, Herb J, Schaefer A PLoS One. 2019; 14(3):e0211571.

PMID: 30840676 PMC: 6402634. DOI: 10.1371/journal.pone.0211571.

A Circuit for Integration of Head- and Visual-Motion Signals in Layer 6 of Mouse Primary Visual Cortex.

Velez-Fort M, Bracey E, Keshavarzi S, Rousseau C, Cossell L, Lenzi S Neuron. 2018; 98(1):179-191.e6.

PMID: 29551490 PMC: 5896233. DOI: 10.1016/j.neuron.2018.02.023.

Performance in a GO/NOGO perceptual task reflects a balance between impulsive and instrumental components of behaviour.

Berditchevskaia A, Caze R, Schultz S Sci Rep. 2016; 6:27389.

PMID: 27272438 PMC: 4895381. DOI: 10.1038/srep27389.

Learning modulation of odor representations: new findings from Arc-indexed networks.

Yuan Q, Harley C Front Cell Neurosci. 2015; 8:423.

PMID: 25565958 PMC: 4271698. DOI: 10.3389/fncel.2014.00423.

References

Wachowiak M, Cohen L . Correspondence between odorant-evoked patterns of receptor neuron input and intrinsic optical signals in the mouse olfactory bulb. J Neurophysiol. 2003; 89(3):1623-39. DOI: 10.1152/jn.00747.2002. View

Stettler D, Axel R . Representations of odor in the piriform cortex. Neuron. 2009; 63(6):854-64. DOI: 10.1016/j.neuron.2009.09.005. View

Wachowiak M, Cohen L . Representation of odorants by receptor neuron input to the mouse olfactory bulb. Neuron. 2001; 32(4):723-35. DOI: 10.1016/s0896-6273(01)00506-2. View

Freeman W . A physiological hypothesis of perception. Perspect Biol Med. 1981; 24(4):561-92. DOI: 10.1353/pbm.1981.0036. View

Aungst J, Heyward P, Puche A, Karnup S, Hayar A, Szabo G . Centre-surround inhibition among olfactory bulb glomeruli. Nature. 2003; 426(6967):623-9. DOI: 10.1038/nature02185. View

Keck T, Mrsic-Flogel T, Vaz Afonso M, Eysel U, Bonhoeffer T, Hubener M . Massive restructuring of neuronal circuits during functional reorganization of adult visual cortex. Nat Neurosci. 2008; 11(10):1162-7. DOI: 10.1038/nn.2181. View

Isaacson J . Odor representations in mammalian cortical circuits. Curr Opin Neurobiol. 2010; 20(3):328-31. PMC: 2896888. DOI: 10.1016/j.conb.2010.02.004. View

Wachowiak M, Denk W, Friedrich R . Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two-photon calcium imaging. Proc Natl Acad Sci U S A. 2004; 101(24):9097-102. PMC: 428479. DOI: 10.1073/pnas.0400438101. View

Johnson B, Leon M . Modular representations of odorants in the glomerular layer of the rat olfactory bulb and the effects of stimulus concentration. J Comp Neurol. 2000; 422(4):496-509. DOI: 10.1002/1096-9861(20000710)422:4<496::aid-cne2>3.0.co;2-4. View

10.

Cleland T, Johnson B, Leon M, Linster C . Relational representation in the olfactory system. Proc Natl Acad Sci U S A. 2007; 104(6):1953-8. PMC: 1794271. DOI: 10.1073/pnas.0608564104. View

11.

Barth T, Jones T, Schallert T . Functional subdivisions of the rat somatic sensorimotor cortex. Behav Brain Res. 1990; 39(1):73-95. DOI: 10.1016/0166-4328(90)90122-u. View

12.

Spors H, Wachowiak M, Cohen L, Friedrich R . Temporal dynamics and latency patterns of receptor neuron input to the olfactory bulb. J Neurosci. 2006; 26(4):1247-59. PMC: 6674558. DOI: 10.1523/JNEUROSCI.3100-05.2006. View

13.

Bisulco S, Slotnick B . Olfactory discrimination of short chain fatty acids in rats with large bilateral lesions of the olfactory bulbs. Chem Senses. 2003; 28(5):361-70. DOI: 10.1093/chemse/28.5.361. View

14.

Mombaerts P, Wang F, Dulac C, CHAO S, Nemes A, Mendelsohn M . Visualizing an olfactory sensory map. Cell. 1996; 87(4):675-86. DOI: 10.1016/s0092-8674(00)81387-2. View

15.

Linster C, Johnson B, Yue E, Morse A, Xu Z, Hingco E . Perceptual correlates of neural representations evoked by odorant enantiomers. J Neurosci. 2001; 21(24):9837-43. PMC: 6763025. View

16.

Uchida N, Mainen Z . Odor concentration invariance by chemical ratio coding. Front Syst Neurosci. 2008; 1:3. PMC: 2526272. DOI: 10.3389/neuro.06.003.2007. View

17.

Costanzo R . Neural regeneration and functional reconnection following olfactory nerve transection in hamster. Brain Res. 1985; 361(1-2):258-66. DOI: 10.1016/0006-8993(85)91297-1. View

18.

Schaefer A, Margrie T . Spatiotemporal representations in the olfactory system. Trends Neurosci. 2007; 30(3):92-100. DOI: 10.1016/j.tins.2007.01.001. View

19.

Choi G, Stettler D, Kallman B, Bhaskar S, Fleischmann A, Axel R . Driving opposing behaviors with ensembles of piriform neurons. Cell. 2011; 146(6):1004-15. PMC: 3230930. DOI: 10.1016/j.cell.2011.07.041. View

20.

Rubin B, Katz L . Spatial coding of enantiomers in the rat olfactory bulb. Nat Neurosci. 2001; 4(4):355-6. DOI: 10.1038/85997. View