Blocking Neurogenic Inflammation for the Treatment of Acute Disorders of the Central Nervous System

Overview

Journal Int J Inflam

Publisher Wiley

Date 2013 Jul 3

PMID 23819099

Citations 13

Authors

Kate Marie Lewis

Renee Jade Turner

Robert Vink

Affiliations

Soon will be listed here.

Abstract

Classical inflammation is a well-characterized secondary response to many acute disorders of the central nervous system. However, in recent years, the role of neurogenic inflammation in the pathogenesis of neurological diseases has gained increasing attention, with a particular focus on its effects on modulation of the blood-brain barrier BBB. The neuropeptide substance P has been shown to increase blood-brain barrier permeability following acute injury to the brain and is associated with marked cerebral edema. Its release has also been shown to modulate classical inflammation. Accordingly, blocking substance P NK1 receptors may provide a novel alternative treatment to ameliorate the deleterious effects of neurogenic inflammation in the central nervous system. The purpose of this paper is to provide an overview of the role of substance P and neurogenic inflammation in acute injury to the central nervous system following traumatic brain injury, spinal cord injury, stroke, and meningitis.

Citing Articles

CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets.

Chen X, Tan Q, Chen K, Zheng D, Deng H, He S Neurochem Res. 2023; 49(3):557-567.

PMID: 38063946 DOI: 10.1007/s11064-023-04077-6.

A Potential Role for Substance P in West Nile Virus Neuropathogenesis.

Ronca S, Gunter S, Kairis R, Lino A, Romero J, Pautler R Viruses. 2022; 14(9).

PMID: 36146768 PMC: 9503494. DOI: 10.3390/v14091961.

NK1-r Antagonist Treatment Comparable to Decompressive Craniectomy in Reducing Intracranial Pressure Following Stroke.

Sorby-Adams A, Leonard A, Hoving J, Yassi N, Vink R, Wells A Front Neurosci. 2019; 13:681.

PMID: 31333402 PMC: 6624444. DOI: 10.3389/fnins.2019.00681.

Neuromuscular dysfunction, independent of gait dysfunction, modulates trabecular bone homeostasis in mice.

Bain S, Huber P, Ausk B, Kwon R, M Gardiner E, Srinivasan S J Musculoskelet Neuronal Interact. 2019; 19(1):79-93.

PMID: 30839306 PMC: 6454260.

Serum melatonin levels are associated with mortality in patients with malignant middle cerebral artery infarction.

Lorente L, Martin M, Abreu-Gonzalez P, Perez-Cejas A, Ramos L, Argueso M J Int Med Res. 2018; 46(8):3268-3277.

PMID: 29848129 PMC: 6134645. DOI: 10.1177/0300060518775008.

References

Bilgen M, Dogan B, Narayana P . In vivo assessment of blood-spinal cord barrier permeability: serial dynamic contrast enhanced MRI of spinal cord injury. Magn Reson Imaging. 2002; 20(4):337-41. DOI: 10.1016/s0730-725x(02)00504-0. View

Holzer P . Neurogenic vasodilatation and plasma leakage in the skin. Gen Pharmacol. 1998; 30(1):5-11. DOI: 10.1016/s0306-3623(97)00078-5. View

Vink R, Nimmo A . Multifunctional drugs for head injury. Neurotherapeutics. 2008; 6(1):28-42. PMC: 5084254. DOI: 10.1016/j.nurt.2008.10.036. View

Annunziata P, Cioni C, Santonini R, Paccagnini E . Substance P antagonist blocks leakage and reduces activation of cytokine-stimulated rat brain endothelium. J Neuroimmunol. 2002; 131(1-2):41-9. DOI: 10.1016/s0165-5728(02)00262-x. View

NAFTCHI N, Abrahams S, St Paul H, LOWMAN E, Schlosser W . Localization and changes of substance P in spinal cord of paraplegic cats. Brain Res. 1978; 153(3):507-13. DOI: 10.1016/0006-8993(78)90335-9. View

Majdan M, Mauritz W, Brazinova A, Rusnak M, Leitgeb J, Janciak I . Severity and outcome of traumatic brain injuries (TBI) with different causes of injury. Brain Inj. 2011; 25(9):797-805. DOI: 10.3109/02699052.2011.581642. View

Okabe T, Hide M, Koro O, Nimi N, Yamamoto S . The release of leukotriene B4 from human skin in response to substance P: evidence for the functional heterogeneity of human skin mast cells among individuals. Clin Exp Immunol. 2001; 124(1):150-6. PMC: 1906021. DOI: 10.1046/j.1365-2249.2001.01486.x. View

Kavelaars A, Broeke D, Jeurissen F, Kardux J, Meijer A, Franklin R . Activation of human monocytes via a non-neurokinin substance P receptor that is coupled to Gi protein, calcium, phospholipase D, MAP kinase, and IL-6 production. J Immunol. 1994; 153(8):3691-9. View

Turner R, Vink R . Combined tissue plasminogen activator and an NK1 tachykinin receptor antagonist: an effective treatment for reperfusion injury following acute ischemic stroke in rats. Neuroscience. 2012; 220:1-10. DOI: 10.1016/j.neuroscience.2012.06.047. View

10.

Cioni C, Renzi D, Calabro A, Annunziata P . Enhanced secretion of substance P by cytokine-stimulated rat brain endothelium cultures. J Neuroimmunol. 1998; 84(1):76-85. DOI: 10.1016/s0165-5728(97)00235-x. View

11.

Memezawa H, Smith M, Siesjo B . Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke. 1992; 23(4):552-9. DOI: 10.1161/01.str.23.4.552. View

12.

Skidgel R, Erdos E . Cleavage of peptide bonds by angiotensin I converting enzyme. Agents Actions Suppl. 1987; 22:289-96. DOI: 10.1007/978-3-0348-9299-5_30. View

13.

Gal P, Kravcukova P, Mokry M, Kluchova D . Chemokines as possible targets in modulation of the secondary damage after acute spinal cord injury: a review. Cell Mol Neurobiol. 2009; 29(6-7):1025-35. PMC: 11506275. DOI: 10.1007/s10571-009-9392-4. View

14.

Popovich P, Horner P, Mullin B, Stokes B . A quantitative spatial analysis of the blood-spinal cord barrier. I. Permeability changes after experimental spinal contusion injury. Exp Neurol. 1996; 142(2):258-75. DOI: 10.1006/exnr.1996.0196. View

15.

Levesque M, Wallman M, Parent R, Sik A, Parent A . Neurokinin-1 and neurokinin-3 receptors in primate substantia nigra. Neurosci Res. 2006; 57(3):362-71. DOI: 10.1016/j.neures.2006.11.002. View

16.

Hokfelt T, Broberger C, Xu Z, Sergeyev V, Ubink R, Diez M . Neuropeptides--an overview. Neuropharmacology. 2000; 39(8):1337-56. DOI: 10.1016/s0028-3908(00)00010-1. View

17.

Freed A, Audus K, Lunte S . Investigation of the metabolism of substance P at the blood-brain barrier using capillary electrophoresis with laser-induced fluorescence detection. Electrophoresis. 2001; 22(17):3778-84. DOI: 10.1002/1522-2683(200109)22:17<3778::AID-ELPS3778>3.0.CO;2-E. View

18.

Tian D, Liu J, Xie M, Zhan Y, Qu W, Yu Z . Tamoxifen attenuates inflammatory-mediated damage and improves functional outcome after spinal cord injury in rats. J Neurochem. 2009; 109(6):1658-67. DOI: 10.1111/j.1471-4159.2009.06077.x. View

19.

Carthew H, Ziebell J, Vink R . Substance P-induced changes in cell genesis following diffuse traumatic brain injury. Neuroscience. 2012; 214:78-83. DOI: 10.1016/j.neuroscience.2012.04.028. View

20.

Reinert M, Khaldi A, Zauner A, Doppenberg E, Choi S, Bullock R . High extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure. Neurosurg Focus. 2006; 8(1):e10. DOI: 10.3171/foc.2000.8.1.2027. View