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[Severe Infections : Causes and Management of Sepsis]

Overview
Specialty General Medicine
Date 2013 Jul 3
PMID 23817897
Citations 2
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Abstract

The sepsis syndrome has only recently been defined as a clinical syndrome but despite its unspecific definition it has evolved rapidly into an important concept. Although specific therapeutic interventions targeting the inflammatory pathway have not yet been effective in treating sepsis, a better understanding of mechanisms leading to organ dysfunction has led to better management of patients with sepsis. Clinical signs of systemic inflammatory response syndrome (SIRS) or sepsis are hallmarks for the definition of severe infections. Current guidelines are presented for the management of a number of severe infectious syndromes.

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[First-line anti-infective treatment in sepsis].

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[Malaria].

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References
1.
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B . Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2002; 345(19):1368-77. DOI: 10.1056/NEJMoa010307. View

2.
Alberti C, Brun-Buisson C, Goodman S, Guidici D, Granton J, Moreno R . Influence of systemic inflammatory response syndrome and sepsis on outcome of critically ill infected patients. Am J Respir Crit Care Med. 2003; 168(1):77-84. DOI: 10.1164/rccm.200208-785OC. View

3.
Audebert F, Hanses F, Schneidewind A, Ehrenstein B, Blaas S, Salzberger B . [Epidemiology of severe sepsis at a German university hospital]. Med Klin (Munich). 2007; 102(3):195-202. DOI: 10.1007/s00063-007-1023-6. View

4.
Baddour L, Wilson W, Bayer A, Fowler Jr V, Bolger A, Levison M . Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the.... Circulation. 2005; 111(23):e394-434. DOI: 10.1161/CIRCULATIONAHA.105.165564. View

5.
Levy M, Fink M, Marshall J, Abraham E, Angus D, Cook D . 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003; 31(4):1250-6. DOI: 10.1097/01.CCM.0000050454.01978.3B. View