Modulation of Immune Function by Polyphenols: Possible Contribution of Epigenetic Factors

Overview

Journal Nutrients

Date 2013 Jul 2

PMID 23812304

Citations 37

Authors

Alejandro Cuevas

Nicolas Saavedra

Luis A Salazar

Dulcineia S P Abdalla

Affiliations

Soon will be listed here.

Abstract

Several biological activities have been described for polyphenolic compounds, including a modulator effect on the immune system. The effects of these biologically active compounds on the immune system are associated to processes as differentiation and activation of immune cells. Among the mechanisms associated to immune regulation are epigenetic modifications as DNA methylation of regulatory sequences, histone modifications and posttranscriptional repression by microRNAs that influences the gene expression of key players involved in the immune response. Considering that polyphenols are able to regulate the immune function and has been also demonstrated an effect on epigenetic mechanisms, it is possible to hypothesize that there exists a mediator role of epigenetic mechanisms in the modulation of the immune response by polyphenols.

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References

Karasawa K, Uzuhashi Y, Hirota M, Otani H . A matured fruit extract of date palm tree (Phoenix dactylifera L.) stimulates the cellular immune system in mice. J Agric Food Chem. 2011; 59(20):11287-93. DOI: 10.1021/jf2029225. View

Malireddy S, Kotha S, Secor J, Gurney T, Abbott J, Maulik G . Phytochemical antioxidants modulate mammalian cellular epigenome: implications in health and disease. Antioxid Redox Signal. 2012; 17(2):327-39. PMC: 3353820. DOI: 10.1089/ars.2012.4600. View

Ishii M, Wen H, Corsa C, Liu T, Coelho A, Allen R . Epigenetic regulation of the alternatively activated macrophage phenotype. Blood. 2009; 114(15):3244-54. PMC: 2759649. DOI: 10.1182/blood-2009-04-217620. View

Wang K, Ping S, Huang S, Hu L, Xuan H, Zhang C . Molecular mechanisms underlying the in vitro anti-inflammatory effects of a flavonoid-rich ethanol extract from chinese propolis (poplar type). Evid Based Complement Alternat Med. 2013; 2013:127672. PMC: 3562570. DOI: 10.1155/2013/127672. View

Gonzalez R, Ballester I, Lopez-Posadas R, Suarez M, Zarzuelo A, Martinez-Augustin O . Effects of flavonoids and other polyphenols on inflammation. Crit Rev Food Sci Nutr. 2011; 51(4):331-62. DOI: 10.1080/10408390903584094. View

Recio M, Andujar I, Rios J . Anti-inflammatory agents from plants: progress and potential. Curr Med Chem. 2012; 19(14):2088-103. DOI: 10.2174/092986712800229069. View

Kolehmainen M, Mykkanen O, Kirjavainen P, Leppanen T, Moilanen E, Adriaens M . Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Mol Nutr Food Res. 2012; 56(10):1501-10. DOI: 10.1002/mnfr.201200195. View

Arranz A, Doxaki C, Vergadi E, Martinez De La Torre Y, Vaporidi K, Lagoudaki E . Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci U S A. 2012; 109(24):9517-22. PMC: 3386059. DOI: 10.1073/pnas.1119038109. View

Kim H, Kim S, Yun J . Fisetin inhibits hyperglycemia-induced proinflammatory cytokine production by epigenetic mechanisms. Evid Based Complement Alternat Med. 2013; 2012:639469. PMC: 3539716. DOI: 10.1155/2012/639469. View

10.

Manach C, Scalbert A, Morand C, Remesy C, Jimenez L . Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004; 79(5):727-47. DOI: 10.1093/ajcn/79.5.727. View

11.

Wu C, Li A, Leng Y, Li Y, Kang J . Histone deacetylase inhibition by sodium valproate regulates polarization of macrophage subsets. DNA Cell Biol. 2011; 31(4):592-9. DOI: 10.1089/dna.2011.1401. View

12.

Zhou B, Wang S, Mayr C, Bartel D, Lodish H . miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A. 2007; 104(17):7080-5. PMC: 1855395. DOI: 10.1073/pnas.0702409104. View

13.

Graff J, Dickson A, Clay G, McCaffrey A, Wilson M . Identifying functional microRNAs in macrophages with polarized phenotypes. J Biol Chem. 2012; 287(26):21816-25. PMC: 3381144. DOI: 10.1074/jbc.M111.327031. View

14.

Schindler R, Mancilla J, Endres S, Ghorbani R, Clark S, Dinarello C . Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood. 1990; 75(1):40-7. View

15.

Zhu J, Paul W . Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev. 2010; 238(1):247-62. PMC: 2975272. DOI: 10.1111/j.1600-065X.2010.00951.x. View

16.

Tsao R . Chemistry and biochemistry of dietary polyphenols. Nutrients. 2012; 2(12):1231-46. PMC: 3257627. DOI: 10.3390/nu2121231. View

17.

Costantino C, Baecher-Allan C, Hafler D . Multiple sclerosis and regulatory T cells. J Clin Immunol. 2008; 28(6):697-706. PMC: 2752287. DOI: 10.1007/s10875-008-9236-x. View

18.

Olivera A, Moore T, Hu F, Brown A, Sun A, Liotta D . Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. Int Immunopharmacol. 2011; 12(2):368-77. PMC: 3372981. DOI: 10.1016/j.intimp.2011.12.009. View

19.

Ivashkiv L . Epigenetic regulation of macrophage polarization and function. Trends Immunol. 2012; 34(5):216-23. PMC: 3647003. DOI: 10.1016/j.it.2012.11.001. View

20.

Cheung P, Lau P . Epigenetic regulation by histone methylation and histone variants. Mol Endocrinol. 2005; 19(3):563-73. DOI: 10.1210/me.2004-0496. View