Histone Deacetylases in Herpesvirus Replication and Virus-stimulated Host Defense

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2013 Jun 29

PMID 23807710

Citations 24

Authors

Amanda J Guise

Hanna G Budayeva

Benjamin A Diner

Ileana M Cristea

Affiliations

Soon will be listed here.

Abstract

Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based "omic" technologies to infectious disease research, offering a systems biology view of infection.

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