Paired Related Homoeobox 1, a New EMT Inducer, is Involved in Metastasis and Poor Prognosis in Colorectal Cancer

Overview

Journal Br J Cancer

Specialty Oncology

Date 2013 Jun 29

PMID 23807160

Citations 56

Authors

Y Takahashi

G Sawada

J Kurashige

R Uchi

T Matsumura

H Ueo

Y Takano

S Akiyoshi

H Eguchi

T Sudo

K Sugimachi

Y Doki

M Mori

K Mimori

Affiliations

Soon will be listed here.

Abstract

Background: Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.

Methods: We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets.

Results: PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC.

Conclusion: PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.

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