Aerobic Training and Angiogenesis Activation in Patients with Stable Chronic Heart Failure: a Preliminary Report

Overview

Journal Biomarkers

Specialty Biochemistry

Date 2013 Jun 29

PMID 23805979

Citations 21

Authors

Ermanno Eleuteri

Alessandro Mezzani

Antonino Di Stefano

Davide Vallese

Isabella Gnemmi

Lorena Delle Donne

Adriano Taddeo

Silvia Della Bella

Pantaleo Giannuzzi

Affiliations

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Abstract

The pathophysiology of chronic heart failure (CHF) involves multiple hystologic and molecular alterations. To determine the effects of physical training on circulating endothelial progenitor cells (EPCs), angiogenesis (angiogenin, angiopoietin-1 and -2, VEGF, Tie-2, SDF-1α) and inflammation (IL-6, CRP), we compared data obtained from 11 CHF pts before and after 3 months aerobic exercise training, to those from 10 non trained CHF pts (CHF-C group, age 64 + 2 years, NYHA 2). At the end of the study, EPCs count and AP-2 serum levels significantly increased in the CHF-TR group. These preliminary data suggest a significant effect of even a short program of physical training on angiogenic activation and endothelial dysfunction.

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