The Unique Expression and Function of MiR-424 in Human Placental Trophoblasts

Overview

Journal Biol Reprod

Publisher Oxford University Press

Specialty Reproductive Medicine

Date 2013 Jun 28

PMID 23803556

Citations 29

Authors

Jean-Francois Mouillet

Rogier B Donker

Takuya Mishima

Tina Cronqvist

Tianjiao Chu

Yoel Sadovsky

Affiliations

Soon will be listed here.

Abstract

Placental hypoperfusion causes cellular hypoxia and is associated with fetal growth restriction and preeclampsia. In response to hypoxia, the repertoire of genes expressed in placental trophoblasts changes, which influences key cellular processes such as differentiation and fusion. Diverse miRNAs were recently found to modulate the cellular response to hypoxia. Here we show that miR-424, which was previously shown to be upregulated by hypoxia in nontrophoblastic cell types, is uniquely downregulated in primary human trophoblasts by hypoxia or chemicals known to hinder cell differentiation. We also identify FGFR1 as a direct target of miR-424 in human trophoblasts. This effect is unique to miR-424 and is not seen with other members of this miRNA family that are expressed in trophoblasts, such as miR-15 and miR-16. Our findings establish a unique role for miR-424 during differentiation of human trophoblasts.

Citing Articles

miR‑424‑5p is downregulated in the placentas of patients with preeclampsia and affects trophoblast migration and invasion.

Zhu W, Chen X Exp Ther Med. 2023; 25(6):294.

PMID: 37229318 PMC: 10203755. DOI: 10.3892/etm.2023.11993.

Ultrasound and microbubble-mediated delivery of miR-424-5p has a therapeutic effect in preeclampsia.

Wang X, Wu Y, Sun Q, Jiang Z, Che G, Tao Y Biol Proced Online. 2023; 25(1):3.

PMID: 36788514 PMC: 9930350. DOI: 10.1186/s12575-023-00191-5.

Intracellular and extracellular factors of colorectal cancer liver metastasis: a pivotal perplex to be fully elucidated.

Niu Y, Yang W, Qian H, Sun Y Cancer Cell Int. 2022; 22(1):341.

PMID: 36348319 PMC: 9644527. DOI: 10.1186/s12935-022-02766-w.

microRNA signatures associated with fetal growth restriction: a systematic review.

Kochhar P, Vukku M, Rajashekhar R, Mukhopadhyay A Eur J Clin Nutr. 2021; 76(8):1088-1102.

PMID: 34741137 DOI: 10.1038/s41430-021-01041-x.

RNA Network Interactions During Differentiation of Human Trophoblasts.

Chu T, Mouillet J, Cao Z, Barak O, Ouyang Y, Sadovsky Y Front Cell Dev Biol. 2021; 9:677981.

PMID: 34150771 PMC: 8209545. DOI: 10.3389/fcell.2021.677981.

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