Ca(2+) Signaling in T-cell Subsets with a Focus on the Role of Cav1 Channels: Possible Implications in Therapeutics

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2013 Jun 27

PMID 23801988

Citations 3

Authors

Lucette Pelletier

M Savignac

Affiliations

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References

Robert V, Triffaux E, Savignac M, Pelletier L . Calcium signalling in T-lymphocytes. Biochimie. 2011; 93(12):2087-94. DOI: 10.1016/j.biochi.2011.06.016. View

Navedo M, Amberg G, Votaw V, Santana L . Constitutively active L-type Ca2+ channels. Proc Natl Acad Sci U S A. 2005; 102(31):11112-7. PMC: 1180225. DOI: 10.1073/pnas.0500360102. View

Kotturi M, Jefferies W . Molecular characterization of L-type calcium channel splice variants expressed in human T lymphocytes. Mol Immunol. 2005; 42(12):1461-74. DOI: 10.1016/j.molimm.2005.01.014. View

Tanaka M, Nyce J . Respirable antisense oligonucleotides: a new drug class for respiratory disease. Respir Res. 2001; 2(1):5-9. PMC: 59563. DOI: 10.1186/rr32. View

Park C, Shcheglovitov A, Dolmetsch R . The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels. Science. 2010; 330(6000):101-5. DOI: 10.1126/science.1191027. View

Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel S, Tanasa B . A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006; 441(7090):179-85. DOI: 10.1038/nature04702. View

Barr V, Bernot K, Shaffer M, Burkhardt J, Samelson L . Formation of STIM and Orai complexes: puncta and distal caps. Immunol Rev. 2009; 231(1):148-59. PMC: 3110759. DOI: 10.1111/j.1600-065X.2009.00812.x. View

Liao P, Soong T . CaV1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency. Pflugers Arch. 2009; 460(2):353-9. DOI: 10.1007/s00424-009-0753-0. View

Robert V, Triffaux E, Savignac M, Pelletier L . Singularities of calcium signaling in effector T-lymphocytes. Biochim Biophys Acta. 2012; 1833(7):1595-602. DOI: 10.1016/j.bbamcr.2012.12.001. View

10.

McRory J, Hamid J, Doering C, Garcia E, Parker R, Hamming K . The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distribution. J Neurosci. 2004; 24(7):1707-18. PMC: 6730460. DOI: 10.1523/JNEUROSCI.4846-03.2004. View

11.

Matza D, Badou A, Kobayashi K, Goldsmith-Pestana K, Masuda Y, Komuro A . A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation. Immunity. 2008; 28(1):64-74. PMC: 2350190. DOI: 10.1016/j.immuni.2007.11.020. View

12.

Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet J . TRPM4 regulates calcium oscillations after T cell activation. Science. 2004; 306(5700):1374-7. DOI: 10.1126/science.1098845. View

13.

Zhou Y, Meraner P, Kwon H, Machnes D, Oh-Hora M, Zimmer J . STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nat Struct Mol Biol. 2009; 17(1):112-6. PMC: 2902271. DOI: 10.1038/nsmb.1724. View

14.

Jha M, Badou A, Meissner M, McRory J, Freichel M, Flockerzi V . Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels. Nat Immunol. 2009; 10(12):1275-82. PMC: 2785134. DOI: 10.1038/ni.1793. View

15.

Fanger C, Neben A, Cahalan M . Differential Ca2+ influx, KCa channel activity, and Ca2+ clearance distinguish Th1 and Th2 lymphocytes. J Immunol. 2000; 164(3):1153-60. DOI: 10.4049/jimmunol.164.3.1153. View

16.

Feske S, Skolnik E, Prakriya M . Ion channels and transporters in lymphocyte function and immunity. Nat Rev Immunol. 2012; 12(7):532-47. PMC: 3670817. DOI: 10.1038/nri3233. View

17.

Santana L, Navedo M . Natural inequalities: why some L-type Ca2+ channels work harder than others. J Gen Physiol. 2010; 136(2):143-7. PMC: 2912067. DOI: 10.1085/jgp.200910391. View

18.

Kotturi M, Hunt S, Jefferies W . Roles of CRAC and Cav-like channels in T cells: more than one gatekeeper?. Trends Pharmacol Sci. 2006; 27(7):360-7. DOI: 10.1016/j.tips.2006.05.007. View

19.

Savignac M, Badou A, Moreau M, Leclerc C, Guery J, Paulet P . Protein kinase C-mediated calcium entry dependent upon dihydropyridine sensitive channels: a T cell receptor-coupled signaling pathway involved in IL-4 synthesis. FASEB J. 2001; 15(9):1577-9. DOI: 10.1096/fj.00-0733fje. View

20.

Dolmetsch R, Lewis R, Goodnow C, Healy J . Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature. 1997; 386(6627):855-8. DOI: 10.1038/386855a0. View