Hemolytic Uremic Syndrome Complicating Mycoplasma Pneumoniae Infection

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2013 Jun 27

PMID 23800801

Citations 5

Authors

Astrid Godron

Sabine Pereyre

Catherine Monet

Brigitte Llanas

Jerome Harambat

Affiliations

Soon will be listed here.

Abstract

Background: Mycoplasma pneumoniae can cause various extrapulmonary manifestations but, to our knowledge, no case of Mycoplasma pneumoniae associated with hemolytic uremic syndrome (HUS) has been reported.

Case-diagnosis/treatment: We describe a 1-year-old boy with M. pneumoniae respiratory tract infection and associated microangiopathic hemolytic anemia, slightly decreased platelet count and mild renal impairment, suggesting a diagnosis of HUS. Assuming M. pneumoniae infection was the cause of HUS in this case, the different possible mechanisms, including an atypical HUS due to preexisting complement dysregulation, an alternative complement pathway activation induced by M. pneumoniae infection at the acute phase, an autoimmune disorder, and a direct role of the bacteria in inducing endothelial injury, are discussed. The signs of HUS resolved with treatment of the M. pneumoniae infection.

Conclusions: Hemolytic uremic syndrome may be an unusual complication of M. pneumoniae infection.

Citing Articles

Correlation of DNA load, genotyping, and clinical phenotype of infection in children.

Wang W, Wang L, Yin Z, Zeng S, Yao G, Liu Y Front Pediatr. 2024; 12:1369431.

PMID: 38655275 PMC: 11035820. DOI: 10.3389/fped.2024.1369431.

A pediatric case of atypical hemolytic uremic syndrome (aHUS): Could any infection play a triggering role?.

Gkiourtzis N, Panagopoulou P, Papadopoulou-Legbelou K, Chantavaridou S, Tramma D Clin Nephrol Case Stud. 2024; 12:32-35.

PMID: 38596164 PMC: 11002780. DOI: 10.5414/CNCS111209.

Infections and Primary Immune Deficiencies.

Poddighe D, Demirkaya E, Sazonov V, Romano M Int J Clin Pract. 2022; 2022:6343818.

PMID: 35855053 PMC: 9286979. DOI: 10.1155/2022/6343818.

Thrombosis associated with infection (Review).

Liu J, Li Y Exp Ther Med. 2021; 22(3):967.

PMID: 34335909 PMC: 8290426. DOI: 10.3892/etm.2021.10399.

Mycoplasma pneumoniae: Current Knowledge on Macrolide Resistance and Treatment.

Pereyre S, Goret J, Bebear C Front Microbiol. 2016; 7:974.

PMID: 27446015 PMC: 4916212. DOI: 10.3389/fmicb.2016.00974.

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