On the Relation Between Citrate and Calcium in Normal and Stone-former Subjects

Overview

Journal Int Urol Nephrol

Publisher Springer

Specialty Nephrology

Date 1990 Jan 1

PMID 2380005

Citations 1

Authors

A Conte

P Roca

M Gianotti

F Grases

Affiliations

Soon will be listed here.

Abstract

The aim of this work is to evaluate citrate in a group of patients with calcium oxalate urolithiasis and in a control group for detecting possible differences between the two groups. The mean urinary concentration in the stone-formers was found significantly lower than in the controls. Particularly interesting was the correlation study between citrate and calcium. It was found that patients with hypocitraturia have hypercalciuria. Thus, it is particularly interesting to point out the importance of citrate in preventing the risk of lithiasis in the group of stone-formers studied by us.

Citing Articles

Urolithiasis, inhibitors and promoters.

Grases F, Conte A Urol Res. 1992; 20(1):86-8.

PMID: 1736493 DOI: 10.1007/BF00294344.

References

Welshman S, McGeown M . Urinary citrate excretion in stone-formers and normal controls. Br J Urol. 1976; 48(1):7-11. DOI: 10.1111/j.1464-410x.1976.tb02731.x. View

Welshman S, McGeown M . A quantitative investigation of the effects on the growth of calcium oxalate crystals on potential inhibitors. Br J Urol. 1972; 44(6):677-80. DOI: 10.1111/j.1464-410x.1972.tb10141.x. View

Grases F, Genestar C, March P, Conte A . Variations in the activity of urinary inhibitors in calcium oxalate urolithiasis. Br J Urol. 1988; 62(6):515-20. DOI: 10.1111/j.1464-410x.1988.tb04417.x. View

Millan A, Conte A, Garcia-Raso A, Grases F . Determination of citrate in urine by simple direct photometry. Clin Chem. 1987; 33(7):1259-60. View

Robertson W, Peacock M, Nordin B . Activity products in stone-forming and non-stone-forming urine. Clin Sci. 1968; 34(3):579-94. View

Elliot J, RIBEIRO M . The urinary excretion of citric, hippuric, and lactic acid in normal adults and in patients with calcium oxalate urinary calculus disease. Invest Urol. 1972; 10(1):102-6. View

SHORR E, Bernheim A, Taussky H . THE RELATION OF URINARY CITRIC ACID EXCRETION TO THE MENSTRUAL CYCLE AND THE STEROIDAL REPRODUCTIVE HORMONES. Science. 1942; 95(2476):606-7. DOI: 10.1126/science.95.2476.606. View

Schwille P, Scholz D, Paulus M, Engelhardt W, Sigel A . Citrate in daily and fasting urine: results of controls, patients with recurrent idiopathic calcium urolithiasis, and primary hyperparathyroidism. Invest Urol. 1979; 16(6):457-62. View

Robertson W, Peacock M, Heyburn P, Marshall D, Clark P . Risk factors in calcium stone disease of the urinary tract. Br J Urol. 1978; 50(7):449-54. DOI: 10.1111/j.1464-410x.1978.tb06189.x. View

10.

Menon M, Mahle C . Urinary citrate excretion in patients with renal calculi. J Urol. 1983; 129(6):1158-60. DOI: 10.1016/s0022-5347(17)52618-x. View

11.

Pylypchuk G, Ehrig U, Wilson D . Idiopathic calcium nephrolithiasis. 1. Differences in urine crystalloids, urine saturation with brushite and urine inhibitors of calcification between persons with and persons without recurrent kidney stone formation. Can Med Assoc J. 1979; 120(6):658-65. PMC: 1819173. View

12.

Robertson W, Peacock M, Nordin B . Calcium oxalate crystalluria and urine saturation in recurrent renal stone-formers. Clin Sci. 1971; 40(5):365-74. DOI: 10.1042/cs0400365. View

13.

Hodgkinson A . Citric acid excretion in normal adults and in patients with renal calculus. Clin Sci. 1962; 23:203-12. View

14.

Nicar M, Skurla C, Sakhaee K, Pak C . Low urinary citrate excretion in nephrolithiasis. Urology. 1983; 21(1):8-14. DOI: 10.1016/0090-4295(83)90113-9. View

15.

Hosking D, Wilson J, Liedtke R, Smith L, Wilson D . Urinary citrate excretion in normal persons and patients with idiopathic calcium urolithiasis. J Lab Clin Med. 1985; 106(6):682-9. View

16.

Butz M . [Oxalate stone prophylaxis by alkalinizing therapy (author's transl)]. Urologe A. 1982; 21(3):142-6. View

17.

RUDMAN D, Kutner M, Redd 2nd S, Waters 4th W, Gerron G, Bleier J . Hypocitraturia in calcium nephrolithiasis. J Clin Endocrinol Metab. 1982; 55(6):1052-7. DOI: 10.1210/jcem-55-6-1052. View