Ankylosing Spondylitis: Chinese Perspective, Clinical Phenotypes, and Associated Extra-articular Systemic Features

Overview

Journal Curr Rheumatol Rep

Publisher Current Science

Specialty Rheumatology

Date 2013 Jun 26

PMID 23797415

Citations 17

Authors

Huei-Huang Ho

Ji-Yih Chen

Affiliations

Soon will be listed here.

Abstract

Ankylosing spondylitis (AS) is a common rheumatic disease in the Chinese population, which is the largest population in the world associated with the global burden of health care. Herein we review and report the epidemiology and specific clinical characteristics of Chinese AS. More than 90 % of Chinese AS patients are HLA-B27 positive with the predominant HLA-B*2704 subtype; the incidence of HLA-B27 positivity ranges from 4 to 8 % in the general Chinese population. The first-degree relatives of AS probands often develop atypical AS with relatively mild disease and particularly undifferentiated spondyloarthropathy in females. Chinese AS patients have higher frequencies of juvenile-onset AS and peripheral arthritis. Of extra-articular manifestations, AS patients have earlier onset and more recurrent attacks of HLA-B27-related acute anterior uveitis. Cardiac arrhythmias or other cardiovascular disorders and metabolic syndrome are not infrequently found. Importantly, apical lung diseases in Chinese AS patients are also frequently associated with tuberculosis infection.

Citing Articles

Changes in Anxiety and Depression After THA in Patients with Ankylosing Spondylitis and the Affecting Factors.

Qian H, Wang X, Wang P, Zhang G, Liu J, Dang X Ther Clin Risk Manag. 2023; 19:675-684.

PMID: 37601141 PMC: 10439721. DOI: 10.2147/TCRM.S415564.

Epidemiological characteristics of ankylosing spondylitis in Guangxi Province of China from 2014 to 2021.

Sun X, Zhou C, Chen L, Huang S, Ye Z, Yi M Arch Med Sci. 2023; 19(4):1049-1058.

PMID: 37560717 PMC: 10408009. DOI: 10.5114/aoms/159343.

Ocular Manifestations of Spondyloarthritis.

Pandey A, Ravindran V Mediterr J Rheumatol. 2023; 34(1):24-29.

PMID: 37223599 PMC: 10201097. DOI: 10.31138/mjr.34.1.24.

Genetics of Ankylosing Spondylitis-Focusing on the Ethnic Difference Between East Asia and Europe.

Wu X, Wang G, Zhang L, Xu H Front Genet. 2021; 12:671682.

PMID: 34194471 PMC: 8236852. DOI: 10.3389/fgene.2021.671682.

Secukinumab Demonstrates Sustained Efficacy and Safety in a Taiwanese Subpopulation With Active Ankylosing Spondylitis: Four-Year Results From a Phase 3 Study, MEASURE 1.

Tseng J, Cheng-Chung Wei J, Deodhar A, Martin R, Porter B, McCreddin S Front Immunol. 2020; 11:561748.

PMID: 33324394 PMC: 7725874. DOI: 10.3389/fimmu.2020.561748.

References

van der Linden S, VALKENBURG H, de Jongh B, Cats A . The risk of developing ankylosing spondylitis in HLA-B27 positive individuals. A comparison of relatives of spondylitis patients with the general population. Arthritis Rheum. 1984; 27(3):241-9. DOI: 10.1002/art.1780270301. View

Solak O, Fidan F, Dundar U, Turel A, Aycicek A, Kavuncu V . The prevalence of obstructive sleep apnoea syndrome in ankylosing spondylitis patients. Rheumatology (Oxford). 2009; 48(4):433-5. DOI: 10.1093/rheumatology/kep021. View

Toussirot E, Bahjaoui-Bouhaddi M, Poncet J, Cappelle S, Henriet M, Wendling D . Abnormal autonomic cardiovascular control in ankylosing spondylitis. Ann Rheum Dis. 1999; 58(8):481-7. PMC: 1752931. DOI: 10.1136/ard.58.8.481. View

Khan M, van der Linden S, Kushner I, VALKENBURG H, Cats A . Spondylitic disease without radiologic evidence of sacroiliitis in relatives of HLA-B27 positive ankylosing spondylitis patients. Arthritis Rheum. 1985; 28(1):40-3. DOI: 10.1002/art.1780280107. View

Chen H, Chen C, Lin Y, Chen P, Chen W, Lu C . Association of bone morphogenetic proteins with spinal fusion in ankylosing spondylitis. J Rheumatol. 2010; 37(10):2126-32. DOI: 10.3899/jrheum.100200. View

Chung Y, Liao H, Lin K, Lin Y, Chou C, Chen C . Prevalence of spondyloarthritis in 504 Chinese patients with HLA-B27-associated acute anterior uveitis. Scand J Rheumatol. 2008; 38(2):84-90. DOI: 10.1080/03009740802385423. View

ONeill T, Harrison B, Yin A, Holt P . Ankylosing spondylitis associated with IgA lambda chain myeloma. Br J Rheumatol. 1997; 36(3):401-2. DOI: 10.1093/rheumatology/36.3.401. View

Borman P, Bodur H, Ak G, Bostan E, Barca N . The coexistence of Behçet's disease and ankylosing spondylitis. Rheumatol Int. 2000; 19(5):195-8. DOI: 10.1007/s002960000052. View

van Halm V, van Denderen J, Peters M, Twisk J, van der Paardt M, van der Horst-Bruinsma I . Increased disease activity is associated with a deteriorated lipid profile in patients with ankylosing spondylitis. Ann Rheum Dis. 2006; 65(11):1473-7. PMC: 1798360. DOI: 10.1136/ard.2005.050443. View

10.

Heeneman S, Daemen M . Cardiovascular risks in spondyloarthritides. Curr Opin Rheumatol. 2007; 19(4):358-62. DOI: 10.1097/BOR.0b013e328133f58e. View

11.

Ng S, Liao Z, Yu D, Chan E, Zhao L, Gu J . Epidemiology of spondyloarthritis in the People's Republic of China: review of the literature and commentary. Semin Arthritis Rheum. 2007; 37(1):39-47. DOI: 10.1016/j.semarthrit.2007.01.003. View

12.

Lee C, Lee S, Chang I, Lu T, Yuan A, Chang T . Spontaneous pneumothorax associated with ankylosing spondylitis. Rheumatology (Oxford). 2005; 44(12):1538-41. DOI: 10.1093/rheumatology/kei077. View

13.

Robinson W, van der Linden S, Khan M, Rentsch H, Cats A, Russell A . HLA-Bw60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients. Arthritis Rheum. 1989; 32(9):1135-41. DOI: 10.1002/anr.1780320912. View

14.

Khan M . Remarkable polymorphism of HLA-B27: an ongoing saga. Curr Rheumatol Rep. 2010; 12(5):337-41. DOI: 10.1007/s11926-010-0126-x. View

15.

Nasution A, Mardjuadi A, Suryadhana N, Daud R, Muslichan S . Higher relative risk of spondyloarthropathies among B27 positive Indonesian Chinese than native Indonesians. J Rheumatol. 1993; 20(6):988-90. View

16.

Braun J, Sieper J . Ankylosing spondylitis. Lancet. 2007; 369(9570):1379-1390. DOI: 10.1016/S0140-6736(07)60635-7. View

17.

Lin Z, Gu J, He P, Gao J, Zuo X, Ye Z . Multicenter validation of the value of BASFI and BASDAI in Chinese ankylosing spondylitis and undifferentiated spondyloarthropathy patients. Rheumatol Int. 2009; 31(2):233-8. PMC: 3025108. DOI: 10.1007/s00296-009-1313-9. View

18.

Brandt J, Maier T, Rudwaleit M, Kuhl U, Hiepe F, Sieper J . Co-occurrence of spondyloarthropathy and connective tissue disease: development of Sjögren's syndrome and mixed connective tissue disease (MCTD) in a patient with ankylosing spondylitis. Clin Exp Rheumatol. 2002; 20(1):80-4. View

19.

OShea F, Boyle E, Riarh R, Tse S, Laxer R, Inman R . Comparison of clinical and radiographic severity of juvenile-onset versus adult-onset ankylosing spondylitis. Ann Rheum Dis. 2008; 68(9):1407-12. DOI: 10.1136/ard.2008.092304. View

20.

Zeng Q . Ankylosing spondylitis in Shantou, China: 15 years' clinical experience. J Rheumatol. 2003; 30(8):1816-21. View