Forkhead Box Proteins: Tuning Forks for Transcriptional Harmony

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2013 Jun 25

PMID 23792361

Citations 375

Authors

Eric W-F Lam

Jan J Brosens

Ana R Gomes

Chuay-Yeng Koo

Affiliations

Soon will be listed here.

Abstract

Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for fine-tuning the spatial and temporal expression of a broad range of genes both during development and in adult tissues. This function is engrained in their ability to integrate a multitude of cellular and environmental signals and to act with remarkable fidelity. Several key members of the FOXA, FOXC, FOXM, FOXO and FOXP subfamilies are strongly implicated in cancer, driving initiation, maintenance, progression and drug resistance. The functional complexities of FOX proteins are coming to light and have established these transcription factors as possible therapeutic targets and putative biomarkers for specific cancers.

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