Early Embryogenesis in Zebrafish is Affected by Bisphenol A Exposure

Overview

Journal Biol Open

Specialty Biology

Date 2013 Jun 22

PMID 23789094

Citations 9

Authors

William K F Tse

Bonnie H Y Yeung

H T Wan

Chris K C Wong

Affiliations

Soon will be listed here.

Abstract

Exposure of a developing embryo or fetus to endocrine disrupting chemicals (EDCs) has been hypothesized to increase the propensity of an individual to develop a disease or dysfunction in his/her later life. Although it is important to understand the effects of EDCs on early development in animals, sufficient information about these effects is not available thus far. This is probably because of the technical difficulties in tracing the continuous developmental changes at different stages of mammalian embryos. The zebrafish, an excellent model currently used in developmental biology, provides new insights to the field of toxicological studies. We used the standard whole-mount in situ hybridization screening protocol to determine the early developmental defects in zebrafish embryos exposed to the ubiquitous pollutant, bisphenol A (BPA). Three stages (60-75% epiboly, 8-10 somite, and prim-5) were selected for in situ screening of different molecular markers, whereas BPA exposure altered early dorsoventral (DV) patterning, segmentation, and brain development in zebrafish embryos within 24 hours of exposure.

Citing Articles

Long-term exposure to environmentally relevant Bisphenol-A levels affects growth, swimming, condition factor, sex ratio and histology of juvenile zebrafish.

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Cytogenetic and developmental toxicity of bisphenol A and bisphenol S in Arbacia lixula sea urchin embryos.

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Bisphenol A Exposure Induces Sensory Processing Deficits in Larval Zebrafish during Neurodevelopment.

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The Role of Estrogen and Thyroid Hormones in Zebrafish Visual System Function.

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Evaluation of the Toxicity of Bisphenol A in Reproduction and Its Effect on Fertility and Embryonic Development in the Zebrafish ().

Goncalves Reis L, Lora-Benitez A, Molina-Lopez A, Mora-Medina R, Ayala-Soldado N, Moyano-Salvago M Int J Environ Res Public Health. 2022; 19(2).

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References

Moens C, Prince V . Constructing the hindbrain: insights from the zebrafish. Dev Dyn. 2002; 224(1):1-17. DOI: 10.1002/dvdy.10086. View

Salian S, Doshi T, Vanage G . Perinatal exposure of rats to Bisphenol A affects the fertility of male offspring. Life Sci. 2009; 85(21-22):742-52. DOI: 10.1016/j.lfs.2009.10.004. View

Zon L, Peterson R . In vivo drug discovery in the zebrafish. Nat Rev Drug Discov. 2005; 4(1):35-44. DOI: 10.1038/nrd1606. View

Oxtoby E, Jowett T . Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development. Nucleic Acids Res. 1993; 21(5):1087-95. PMC: 309267. DOI: 10.1093/nar/21.5.1087. View

Gluckman P, Hanson M, Bateson P, Beedle A, Law C, Bhutta Z . Towards a new developmental synthesis: adaptive developmental plasticity and human disease. Lancet. 2009; 373(9675):1654-7. DOI: 10.1016/S0140-6736(09)60234-8. View

Riu A, Grimaldi M, le Maire A, Bey G, Phillips K, Boulahtouf A . Peroxisome proliferator-activated receptor γ is a target for halogenated analogs of bisphenol A. Environ Health Perspect. 2011; 119(9):1227-32. PMC: 3230400. DOI: 10.1289/ehp.1003328. View

Kunz N, Camm E, Somm E, Lodygensky G, Darbre S, Aubert M . Developmental and metabolic brain alterations in rats exposed to bisphenol A during gestation and lactation. Int J Dev Neurosci. 2010; 29(1):37-43. DOI: 10.1016/j.ijdevneu.2010.09.009. View

Joyner A, Guillemot F . Gene targeting and development of the nervous system. Curr Opin Neurobiol. 1994; 4(1):37-42. DOI: 10.1016/0959-4388(94)90029-9. View

Ekker M, Wegner J, Akimenko M, Westerfield M . Coordinate embryonic expression of three zebrafish engrailed genes. Development. 1992; 116(4):1001-10. DOI: 10.1242/dev.116.4.1001. View

10.

Gluckman P, Hanson M, Pinal C . The developmental origins of adult disease. Matern Child Nutr. 2006; 1(3):130-41. PMC: 6860944. DOI: 10.1111/j.1740-8709.2005.00020.x. View

11.

Zoeller R, Bansal R, Parris C . Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain. Endocrinology. 2004; 146(2):607-12. DOI: 10.1210/en.2004-1018. View

12.

Hanson M, Gluckman P . Developmental origins of health and disease: new insights. Basic Clin Pharmacol Toxicol. 2008; 102(2):90-3. DOI: 10.1111/j.1742-7843.2007.00186.x. View

13.

Stachel S, Grunwald D, Myers P . Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish. Development. 1993; 117(4):1261-74. DOI: 10.1242/dev.117.4.1261. View

14.

Duan Z, Zhu L, Zhu L, Kun Y, Zhu X . Individual and joint toxic effects of pentachlorophenol and bisphenol A on the development of zebrafish (Danio rerio) embryo. Ecotoxicol Environ Saf. 2008; 71(3):774-80. DOI: 10.1016/j.ecoenv.2008.01.021. View

15.

Wigle D, Arbuckle T, Turner M, Berube A, Yang Q, Liu S . Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J Toxicol Environ Health B Crit Rev. 2008; 11(5-6):373-517. DOI: 10.1080/10937400801921320. View

16.

Tando S, Itoh K, Yaoi T, Ikeda J, Fujiwara Y, Fushiki S . Effects of pre- and neonatal exposure to bisphenol A on murine brain development. Brain Dev. 2006; 29(6):352-6. DOI: 10.1016/j.braindev.2006.10.003. View

17.

Moriyama K, Tagami T, Akamizu T, Usui T, Saijo M, Kanamoto N . Thyroid hormone action is disrupted by bisphenol A as an antagonist. J Clin Endocrinol Metab. 2002; 87(11):5185-90. DOI: 10.1210/jc.2002-020209. View

18.

Rhind S . Endocrine disruptors and other food-contaminating environmental pollutants as risk factors in animal reproduction. Reprod Domest Anim. 2008; 43 Suppl 2:15-22. DOI: 10.1111/j.1439-0531.2008.01138.x. View

19.

Joly J, Joly C, Schulte-Merker S, Boulekbache H, Condamine H . The ventral and posterior expression of the zebrafish homeobox gene eve1 is perturbed in dorsalized and mutant embryos. Development. 1993; 119(4):1261-75. DOI: 10.1242/dev.119.4.1261. View

20.

Heisenberg C, Brand M, Jiang Y, Warga R, Beuchle D, van Eeden F . Genes involved in forebrain development in the zebrafish, Danio rerio. Development. 1996; 123:191-203. DOI: 10.1242/dev.123.1.191. View