Noninvasive Indicators of Atherosclerosis in Subclinical Hypothyroidism

Overview

Journal Indian J Endocrinol Metab

Specialty Endocrinology

Date 2013 Jun 19

PMID 23776901

Citations 6

Authors

Ismail Dogu Kilic

Halil Tanriverdi

Semin Fenkci

Fulya Akin

Sukriye Uslu

Asuman Kaftan

Affiliations

Soon will be listed here.

Abstract

Introduction: Cardiovascular system is rich in thyroid hormone receptors and is one of the major sites of action for thyroid hormones. However, the effect of subclinical hypothyroidism (SCH) on atherosclerosis has not been cleared yet.

Materials And Methods: SCH is defined as high thyroid-stimulating hormone (TSH) levels in the presence of normal serum T4 and T3 levels. A total of 32 patients with SCH and 29 controls were included in the study. Carotid intima-media thickness, flow-mediated dilatation, and aortic distensibility were compared between the groups.

Results: FMD was lower in patients with SCH than in controls. GTN-induced vasodilatation was similar in the patients with SCH and controls. There was no statistically significant difference between the patients with SCH and controls with respect to CIMT and aortic distensibility.

Conclusion: SCH is associated with endothelial dysfunction as established by FMD. Inconsistent results of CIMT and aortic stiffness can be explained by these parameters being measures of structural changes whereas FMD is a dynamic measure that reflects the impact of both acute and chronic influences on endothelial function.

Citing Articles

Metabolic Syndrome, Thyroid Dysfunction, and Cardiovascular Risk: The Triptych of Evil.

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The Relationship between Subclinical Hypothyroidism and Carotid Intima-Media Thickness as a Potential Marker of Cardiovascular Risk: A Systematic Review and a Meta-Analysis.

Isaila O, Stoian V, Fulga I, Piraianu A, Hostiuc S J Cardiovasc Dev Dis. 2024; 11(4).

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Utility of Epicardial Fat Thickness in Subclinical Hypothyroid Children to Determine Existence of Subclinical Atherosclerosis in Them.

Sahu M, Mishra I, Baliarsinha A, Choudhury A, Routray S Indian J Endocrinol Metab. 2023; 26(5):483-489.

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Arterial Stiffness in Thyroid and Parathyroid Disease: A Review of Clinical Studies.

Grillo A, Barbato V, Antonello R, Cola M, Parati G, Salvi P J Clin Med. 2022; 11(11).

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FMD and CIMT: Surrogate Markers of Atherosclerosis in Subclinical and Overt Hypothyroidism in Sub Himalyan Region.

Kumari B, Kumar B, Gupta D, Ganju N Indian J Endocrinol Metab. 2021; 25(3):220-225.

PMID: 34760677 PMC: 8547403. DOI: 10.4103/ijem.IJEM_247_21.

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