Converging Paths to Progress for Skull Base Chordoma: Review of Current Therapy and Future Molecular Targets

Overview

Journal Surg Neurol Int

Specialty Neurology

Date 2013 Jun 19

PMID 23776758

Citations 5

Authors

Salvatore Di Maio

Esther Kong

Stephen Yip

Robert Rostomily

Affiliations

Soon will be listed here.

Abstract

Background: Chordomas of the skull base are rare locally aggressive neoplasms with a predilection for encapsulating critical neurovascular structures, bony destruction and irregular growth patterns, and from which patients succumb to recurrence and treatment failures.

Methods: A review of the medical literature is performed, using standard search engines and identifying articles related to skull base chordomas, surgery, radiation therapy, chemotherapy, molecular genetics, and prospective trials.

Results: A synthesis of the literature is presented, including sections on pathology, treatment, molecular genetics, challenges, and future directions.

Conclusion: Beyond an understanding of the current treatment paradigms for skull base chordomas, the reader gains insight into the collaborative approach applied to orphan diseases, of which chordomas is a prime exemplar.

Citing Articles

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Craniovertebral junction chordomas: Case series and strategies to overcome the surgical challenge.

Baldassarre B, Di Perna G, Portonero I, Penner F, Cofano F, De Marco R J Craniovertebr Junction Spine. 2022; 12(4):420-431.

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Intracranial chordoma: radiosurgery, hypofractionated stereotactic radiotherapy and treatment outcomes.

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Peri-operative prognostic factors for primary skull base chordomas: results from a single-center cohort.

La Corte E, Broggi M, Raggi A, Schiavolin S, Acerbi F, Danesi G Acta Neurochir (Wien). 2020; 163(3):689-697.

PMID: 31950268 DOI: 10.1007/s00701-020-04219-7.

Novel targeted therapies in chordoma: an update.

Di Maio S, Yip S, Al Zhrani G, Alotaibi F, Al Turki A, Kong E Ther Clin Risk Manag. 2015; 11:873-83.

PMID: 26097380 PMC: 4451853. DOI: 10.2147/TCRM.S50526.

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