Ion Selectivity and Gating Mechanisms of FNT Channels

Overview

Journal Curr Opin Struct Biol

Date 2013 Jun 19

PMID 23773802

Citations 12

Authors

Andrew B Waight

Bryan K Czyzewski

Da-Neng Wang

Affiliations

Soon will be listed here.

Abstract

The phospholipid bilayer has evolved to be a protective and selective barrier by which the cell maintains high concentrations of life sustaining organic and inorganic material. As gatekeepers responsible for an immense amount of bidirectional chemical traffic between the cytoplasm and extracellular milieu, ion channels have been studied in detail since their postulated existence nearly three-quarters of a century ago. Over the past fifteen years, we have begun to understand how selective permeability can be achieved for both cationic and anionic ions. Our mechanistic knowledge has expanded recently with studies of a large family of anion channels, the Formate Nitrite Transport (FNT) family. This family has proven amenable to structural studies at a resolution high enough to reveal intimate details of ion selectivity and gating. With five representative members having yielded a total of 15 crystal structures, this family represents one of the richest sources of structural information for anion channels.

Citing Articles

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