The Effect of Food Hardness on the Development of Dental Caries in Alloxan-induced Diabetic Rats

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2013 Jun 14

PMID 23762876

Citations 1

Authors

Yutaka Nakahara

Tomoya Sano

Yasushi Kodama

Kiyokazu Ozaki

Tetsuro Matsuura

Affiliations

Soon will be listed here.

Abstract

We have previously shown that dental caries may be produced in diabetic rodent models fed with noncariogenic standard diets; however, many studies usually add large amounts of sugar to the diet to induce dental caries. Moreover, the physical properties of cariogenic diets have been reported as an important factor in the formation of caries. The aim of this study was to clarify the effect of the hardness of non-cariogenic diets on the development of dental caries in diabetic rodents. Seven-week-old female F344 rats were divided into 4 groups: intact rats fed with a standard pelletized or powdered diet and alloxan-induced diabetic rats fed with a standard pelletized or powdered diet. All of the rats were sacrificed at 52 weeks of age for morphological examinations on their dental tissue. Dental caries had developed and extended to all the molars in the diabetic rats that were fed with both the pelletized and powdered diets. Moreover, the lesion was significantly enhanced in the powdered diet group compared to that in the pelletized diet group. In conclusion, food hardness is an important factor influencing the development of dental caries in diabetic rats.

Citing Articles

Vitamin D Supplementation, Characteristics of Mastication, and Parent-Supervised Toothbrushing as Crucial Factors in the Prevention of Caries in 12- to 36-Month-Old Children.

Sobiech P, Olczak-Kowalczyk D, Hosey M, Gozdowski D, Turska-Szybka A Nutrients. 2022; 14(20).

PMID: 36297042 PMC: 9607142. DOI: 10.3390/nu14204358.

References

Miralles L, Silvestre F, Hernandez-Mijares A, Bautista D, Llambes F, Grau D . Dental caries in type 1 diabetics: influence of systemic factors of the disease upon the development of dental caries. Med Oral Patol Oral Cir Bucal. 2006; 11(3):E256-60. View

Nakahara Y, Sano T, Kodama Y, Ozaki K, Matsuura T . Alloxan-induced hyperglycemia causes rapid-onset and progressive dental caries and periodontitis in F344 rats. Histol Histopathol. 2012; 27(10):1297-306. DOI: 10.14670/HH-27.1297. View

McCLURE F . Observations on induced caries in rats; effects of excessive sugar in the diet. J Dent Res. 2010; 24:239-45. DOI: 10.1177/00220345450240050401. View

CALDWELL R . Physical properties of foods and their caries-producing potential. J Dent Res. 1970; 49(6):1293-8. DOI: 10.1177/00220345700490062101. View

HARTLES R, Leach S . Effect of diet on dental caries. Br Med Bull. 1975; 31(2):137-41. DOI: 10.1093/oxfordjournals.bmb.a071267. View

Canepari P, Zerman N, Cavalleri G . Lack of correlation between salivary Streptococcus mutans and lactobacilli counts and caries in IDDM children. Minerva Stomatol. 1994; 43(11):501-5. View

Shaw J . Effects of dietary composition on tooth decay in the albino rat. J Nutr. 1950; 41(1):13-24. DOI: 10.1093/jn/41.1.13. View

NAVIA J, Lopez H . Sources of variability in rat caries studies: weaning age and diet fed during tooth eruption. J Dent Res. 1977; 56(3):222-7. DOI: 10.1177/00220345770560030501. View

Kandelman D . Sugar, alternative sweeteners and meal frequency in relation to caries prevention: new perspectives. Br J Nutr. 1997; 77 Suppl 1:S121-8. DOI: 10.1079/bjn19970109. View

10.

STRALFORS A, Thilander H, BERGENHOLTZ A . Caries and periodontal disease in hamsters fed cereal foods varying in sugar content and hardness. Arch Oral Biol. 1967; 12(12):1361-5. DOI: 10.1016/0003-9969(67)90174-4. View

11.

SOGNNAES R . Experimental rat caries; location, sequence and extent of carious lesions produced in the Norway rat when raised on a generally adequate, finely powdered, purified ration. J Nutr. 1949; 39(2):139-46, incl 2 pl. DOI: 10.1093/jn/39.2.139. View

12.

Iughetti L, Marino R, Bertolani M, Bernasconi S . Oral health in children and adolescents with IDDM--a review. J Pediatr Endocrinol Metab. 2000; 12(5):603-10. View

13.

HARTLES R, LAWTON F, SLACK G . Experimental dental caries in the albino rat; the production of carious lesions in animals maintained on a finely powdered purified diet containing 67% sucrose. Br J Nutr. 1956; 10(3):234-40. DOI: 10.1079/bjn19560035. View

14.

Sano T, Matsuura T, Ozaki K, Narama I . Dental caries and caries-related periodontitis in type 2 diabetic mice. Vet Pathol. 2010; 48(2):506-12. DOI: 10.1177/0300985810380394. View

15.

FROSTELL G, Keyes P, LARSON R . Effect of various sugars and sugar substitutes on dental caries in hamsters and rats. J Nutr. 1967; 93(1):65-76. DOI: 10.1093/jn/93.1.65. View

16.

Kodama Y, Matsuura M, Sano T, Nakahara Y, Ozaki K, Narama I . Diabetes enhances dental caries and apical periodontitis in caries-susceptible WBN/KobSlc rats. Comp Med. 2011; 61(1):53-9. PMC: 3060429. View

17.

Stewart W, HOPPERT C, HUNT H . The incidence of dental caries in caries-susceptible and caries-resistant albino rats (Rattus norvegicus) when fed diets containing granulated and powdered sucrose. J Dent Res. 1953; 32(2):210-4. DOI: 10.1177/00220345530320020701. View

18.

Lamster I, Lalla E, Borgnakke W, Taylor G . The relationship between oral health and diabetes mellitus. J Am Dent Assoc. 2008; 139 Suppl:19S-24S. DOI: 10.14219/jada.archive.2008.0363. View