Adaptive Immunity, Inflammation, and Cardiovascular Complications in Type 1 and Type 2 Diabetes Mellitus

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2013 Jun 14

PMID 23762872

Citations 27

Authors

Daniela Pedicino

Giovanna Liuzzo

Francesco Trotta

Ada Francesca Giglio

Simona Giubilato

Francesca Martini

Francesco Zaccardi

Giuseppe Scavone

Marco Previtero

Gianluca Massaro

Pio Cialdella

Maria Teresa Cardillo

Dario Pitocco

Giovanni Ghirlanda

Filippo Crea

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β -cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.

Citing Articles

Impact of Type 1 Versus Type 2 Diabetes on Developing Herpes Zoster and Post-herpetic Neuralgia: A Population-based Cohort Study.

Wen S, Ou-Yang C, Chang C, Chen C, Chang H Acta Derm Venereol. 2023; 103:adv9400.

PMID: 37787418 PMC: 10561104. DOI: 10.2340/actadv.v103.9400.

Meta-Inflammation and New Anti-Diabetic Drugs: A New Chance to Knock Down Residual Cardiovascular Risk.

DAiello A, Bonanni A, Vinci R, Pedicino D, Severino A, De Vita A Int J Mol Sci. 2023; 24(10).

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Acceptability of Herpes Zoster Vaccination among Patients with Diabetes: A Cross-Sectional Study in Saudi Arabia.

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[Role of CD4NKG2D T cells in the disease activity of juvenile idiopathic arthritis].

Wang J, Zhu X, Zhang Y, Luo C, Tang X, Zhou J Zhongguo Dang Dai Er Ke Za Zhi. 2023; 25(2):166-171.

PMID: 36854693 PMC: 9979394. DOI: 10.7499/j.issn.1008-8830.2208103.

Platelet Mediated Inflammation in Coronary Artery Disease with Type 2 Diabetes Patients.

Johny E, Bhaskar P, Alam M, Kuladhipati I, Das R, Adela R J Inflamm Res. 2021; 14:5131-5147.

PMID: 34675593 PMC: 8504552. DOI: 10.2147/JIR.S326716.

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