Treatment of Nail Psoriasis: Common Concepts and New Trends

Overview

Journal Dermatol Res Pract

Publisher Wiley

Specialty Dermatology

Date 2013 Jun 14

PMID 23762032

Citations 2

Authors

Yasemin Oram

A Deniz Akkaya

Affiliations

Soon will be listed here.

Abstract

The lifetime incidence of nail involvement in psoriatic patients is estimated to be 80-90%, and the nails can be affected in 10% to 55% of psoriatic patients. Psoriasis may also solely involve the nails, without any other skin findings, in which the treatment can be more challenging. Nail psoriasis may lead to considerable impairment in quality of life due to aesthetic concerns and more importantly limitations in daily activities resulting from the associated pain, which may be overlooked by the physicians. Several topical and systemic treatment modalities, as well as radiation and light systems, have been used in the treatment of nail psoriasis. In the last decade, the introduction of biologic agents and the utilization of laser systems have brought a new insight into the treatment of nail psoriasis. This paper focuses on the recent advances, as well as the conventional methods, in treating nail psoriasis in adults and children, in reference to an extensive literature search.

Citing Articles

Fractional CO laser in the treatment of nail psoriasis: how can it help?.

Afify A, Shaheen M, El-Banna M Arch Dermatol Res. 2023; 315(6):1705-1715.

PMID: 36809406 PMC: 10338575. DOI: 10.1007/s00403-023-02574-w.

Pulsed-dye Laser Versus Intralesional Steroid in the Management of Nail Psoriasis: A Randomized, Intra-patient, Comparative, Controlled Study.

Soliman M, Aal H, Sadek A, Tawfik A J Clin Aesthet Dermatol. 2022; 14(9):45-49.

PMID: 34980971 PMC: 8675333.

References

Syuto T, Abe M, Ishibuchi H, Ishikawa O . Successful treatment of psoriatic nails with low-dose cyclosporine administration. Eur J Dermatol. 2007; 17(3):248-9. DOI: 10.1684/ejd.2007.0163. View

Nakamura R, de Abreu L, Duque-Estrada B, Tamler C, Leverone A . Comparison of nail lacquer clobetasol efficacy at 0.05%, 1% and 8% in nail psoriasis treatment: prospective, controlled and randomized pilot study. An Bras Dermatol. 2012; 87(2):203-11. DOI: 10.1590/s0365-05962012000200003. View

Rados J, Dobric I, Pasic A, Lipozencic J, Ledic-Drvar D, Stajminger G . Normalization in the appearance of severly damaged psoriatic nails using soft x-rays. A case report. Acta Dermatovenerol Croat. 2007; 15(1):27-32. View

Gumusel M, Ozdemir M, Mevlitoglu I, Bodur S . Evaluation of the efficacy of methotrexate and cyclosporine therapies on psoriatic nails: a one-blind, randomized study. J Eur Acad Dermatol Venereol. 2010; 25(9):1080-4. DOI: 10.1111/j.1468-3083.2010.03927.x. View

Liang C, Lin T, Lin Y . Successful treatment of pediatric nail psoriasis with periodic pustular eruption using topical indigo naturalis oil extract. Pediatr Dermatol. 2012; 30(1):117-9. DOI: 10.1111/j.1525-1470.2012.01721.x. View

Cassell S, Bieber J, Rich P, Tutuncu Z, Lee S, Kalunian K . The modified Nail Psoriasis Severity Index: validation of an instrument to assess psoriatic nail involvement in patients with psoriatic arthritis. J Rheumatol. 2007; 34(1):123-9. View

Gomez Vazquez M, Navarra Amayuelas R . Marked improvement in nail psoriasis during treatment with etanercept. Dermatol Ther. 2012; 24(5):498-500. DOI: 10.1111/j.1529-8019.2012.01472.x. View

Puig L, Morales-Munera C, Lopez-Ferrer A, Geli C . Ustekinumab treatment of TNF antagonist-induced paradoxical psoriasis flare in a patient with psoriatic arthritis: case report and review. Dermatology. 2012; 225(1):14-7. DOI: 10.1159/000339864. View

Bianchi L, Soda R, Diluvio L, Chimenti S . Tazarotene 0.1% gel for psoriasis of the fingernails and toenails: an open, prospective study. Br J Dermatol. 2003; 149(1):207-9. DOI: 10.1046/j.1365-2133.2003.05392.x. View

10.

Tosti A, Ricotti C, Romanelli P, Cameli N, Piraccini B . Evaluation of the efficacy of acitretin therapy for nail psoriasis. Arch Dermatol. 2009; 145(3):269-71. DOI: 10.1001/archdermatol.2008.600. View

11.

de Berker D . Management of psoriatic nail disease. Semin Cutan Med Surg. 2009; 28(1):39-43. DOI: 10.1016/j.sder.2008.12.003. View

12.

De Simone C, Maiorino A, Tassone F, DAgostino M, Caldarola G . Tacrolimus 0.1% ointment in nail psoriasis: a randomized controlled open-label study. J Eur Acad Dermatol Venereol. 2012; 27(8):1003-6. DOI: 10.1111/j.1468-3083.2012.04642.x. View

13.

Scher R, Stiller M, Zhu Y . Tazarotene 0.1% gel in the treatment of fingernail psoriasis: a double-blind, randomized, vehicle-controlled study. Cutis. 2002; 68(5):355-8. View

14.

Reich K, Langley R, Papp K, Ortonne J, Unnebrink K, Kaul M . A 52-week trial comparing briakinumab with methotrexate in patients with psoriasis. N Engl J Med. 2011; 365(17):1586-96. DOI: 10.1056/NEJMoa1010858. View

15.

Usmani N, Wilson C . A case of nail psoriasis treated with topical calcitriol. Clin Exp Dermatol. 2006; 31(5):712-3. DOI: 10.1111/j.1365-2230.2006.02167.x. View

16.

Feliciani C, Zampetti A, Forleo P, Cerritelli L, Amerio P, Proietto G . Nail psoriasis: combined therapy with systemic cyclosporin and topical calcipotriol. J Cutan Med Surg. 2004; 8(2):122-5. DOI: 10.1007/s10227-004-0114-8. View

17.

Saricaoglu H, Oz A, Turan H . Nail psoriasis successfully treated with intralesional methotrexate: case report. Dermatology. 2011; 222(1):5-7. DOI: 10.1159/000323004. View

18.

Mahrle G, Schulze H, Farber L, Weidinger G, Steigleder G . Low-dose short-term cyclosporine versus etretinate in psoriasis: improvement of skin, nail, and joint involvement. J Am Acad Dermatol. 1995; 32(1):78-88. DOI: 10.1016/0190-9622(95)90189-2. View

19.

Parrish C, Sobera J, Robbins C, Cantrell W, Desmond R, Elewski B . Alefacept in the treatment of psoriatic nail disease: a proof of concept study. J Drugs Dermatol. 2006; 5(4):339-40. View

20.

Rigopoulos D, Gregoriou S, Lazaridou E, Belyayeva E, Apalla Z, Makris M . Treatment of nail psoriasis with adalimumab: an open label unblinded study. J Eur Acad Dermatol Venereol. 2009; 24(5):530-4. DOI: 10.1111/j.1468-3083.2009.03453.x. View