The Evolution of the Cancer Niche During Multistage Carcinogenesis

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2013 Jun 14

PMID 23760023

Citations 127

Authors

Mary Helen Barcellos-Hoff

David Lyden

Timothy C Wang

Affiliations

Soon will be listed here.

Abstract

The concept of the tumour microenvironment recognizes that the interplay between cancer cells and stromal cells is a crucial determinant of cancer growth. In this Perspectives article, we propose the novel concept that the tumour microenvironment is built through rate-limiting steps during multistage carcinogenesis. Construction of a 'precancer niche' is a necessary and early step that is required for initiated cells to survive and evolve; subsequent niche expansion and maturation accompany tumour promotion and progression, respectively. As such, cancer niches represent an emergent property of a tumour that could be a robust target for cancer prevention and therapy.

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